1️⃣ DMChronoTx-Hypo DM · chronotherapy 3D
디엠크로노테라피하이포 — DM 약물 dosing time × circadian biomarker × glycemic outcome 3D chronotherapy 가설 채굴기
PubMed/EuropePMC/bioRxiv/medRxiv/CT.gov/WHO ICTRP chronotherapy mining → 약물(50종 DM·HTN·dyslipidemia·closed-loop AID) × 시각 split(AM/PM/bedtime/morning vs evening/once-weekly weekday·time-of-day) × outcome(HbA1c·CGM TIR/TAR/TBR/MAGE·dawn phenomenon·hypo rate·DKA·HRV·sleep·melatonin·cortisol·BP dipping·hyperkalemia·LDL diurnal) 3D ontology + novelty score(1−published/expected) + Korean cohort suitability(NHIS-HEALS·KoGES·HEXA·NHIS Senior·K-CURE) + 진료환경 feasibility + FDA/EMA/MFDS 라벨·KDA/ADA/EASD 가이드라인 cross-link + 한국어 hypothesis card + SPIRIT protocol skeleton + KHIDI/NRF/NIH/IIT proposal abstract. CLI: --top / --drug / --card / --protocol / --proposal / --stats.
top 8 미탐색 cell
한국어 hypothesis card
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2️⃣ ObesityResponderSubpheno Obesity · responder 4D
오베시티리스폰서서브페노 — 항비만약 subphenotype × drug class × time-to-response × maintenance 4D responder mining 가설 생성기
PubMed/EuropePMC/bioRxiv/medRxiv/CT.gov/WHO ICTRP + 항비만약 RCT published KM auto-digitize + RWE registry → subphenotype(monogenic LEPR/MC4R/POMC/BBS·hypothalamic·hyperandrogenic PCOS/CAH·sarcopenic obesity·hepatic-predominant MASLD/MASH·adipose-predominant·post-bariatric weight regain·adolescent) × drug class(GLP-1·GLP-1/GIP·triple·oral GLP-1·MariTide·CagriSema·survodutide·setmelanotide·기본) × time-to-response(4·12·24·52·68·104주) × maintenance(persistence·rebound·post-discontinuation·dose taper) 4D ontology + 미탐색 cell ranking + Korean cohort suitability(KORACO·BBStopCoach RWE·NHIS 비만 처방·KoGES adolescent obesity) + 한국어 hypothesis card + SPIRIT protocol skeleton + KHIDI/NRF/Novo/Lilly/BI/Amgen/Pfizer IIT abstract. CLI: --top / --subpheno / --drug / --card / --protocol / --proposal / --summary.
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한국어 hypothesis card
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3️⃣ MASLDOrganoCrosstalk MASLD · multi-organ 4-tuple
매슬드오르가노크로스토크 — MASLD/MASH multi-organ crosstalk graph organ × organ × mediator × outcome 4-tuple 가설 생성기
PubMed/EuropePMC/bioRxiv/medRxiv/CT.gov/WHO ICTRP + STRING-DB/Reactome/KEGG/BioGRID interactome → 12+ organ pairwise(liver·gut·adipose·BAT·muscle·bone·brain·kidney·heart·thyroid·gonad·pancreas·immune) × mediator(cytokine·hormone·myokine·hepatokine·adipokine·osteokine·incretin·bile acid·SCFA·lipid·miRNA·exosome) × outcome(MASLD·MASH·fibrosis F0-F4·HCC·CV·DKD·sarcopenia·osteoporosis·hypogonadism·DM) 4-tuple ontology + 미탐색 cell ranking + Korean cohort suitability(KASL multicenter·Boramae·Severance·서울대 MASLD registry·KoGES·NHIS·K-CURE) + MASLD/MASH 약물(resmetirom·pegozafermin·efruxifermin·survodutide·MariTide·CagriSema·tirzep·sema·OCA·aldafermin·lanifibranor·denifanstat·tropifexor·VK2809) cross-organ mechanism + AASLD/EASL/APASL/KASL/NICE 가이드라인 cite + MASLDStager 확장 export + Yggdrasil JSON-LD export. CLI: --top / --organ-pair / --drug / --card / --protocol / --proposal / --export-stager / --export-yggdrasil.
top 8 미탐색 4-tuple
한국어 hypothesis card
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