{
  "schema_version": "1.0",
  "generated": "2026-05-14",
  "description": "LITMUS (EU IMI) + NIMBLE (NIDDK/FNIH) consortium milestone mock dataset",
  "milestones": [
    {
      "milestone_id": "LITMUS-2024-01",
      "consortium": "LITMUS",
      "title": "Final qualification submission package for ELF, FAST, MAST",
      "date": "2024-09-30",
      "deliverable": "Joint FDA BQP + EMA QO dossiers",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-001", "BMK-004", "BMK-005"]
    },
    {
      "milestone_id": "LITMUS-2024-02",
      "consortium": "LITMUS",
      "title": "DeLIVER primary care cohort interim analysis (n=4,321)",
      "date": "2024-11-18",
      "deliverable": "FIB-4 + VCTE two-step pathway performance report",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-003", "BMK-008"]
    },
    {
      "milestone_id": "LITMUS-2025-01",
      "consortium": "LITMUS",
      "title": "Imaging panel composite endpoint analysis",
      "date": "2025-04-22",
      "deliverable": "MRE + cT1 + MRI-PDFF composite vs paired biopsy n=966",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-006", "BMK-007", "BMK-013", "BMK-039"]
    },
    {
      "milestone_id": "NIMBLE-2024-01",
      "consortium": "NIMBLE",
      "title": "Paired biopsy circulating biomarker round 2 results",
      "date": "2024-12-05",
      "deliverable": "PRO-C3, ELF, NIS4 head-to-head AUROC report",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-001", "BMK-002", "BMK-011"]
    },
    {
      "milestone_id": "NIMBLE-2025-01",
      "consortium": "NIMBLE",
      "title": "Imaging consortium harmonization protocol v2",
      "date": "2025-03-14",
      "deliverable": "Multi-vendor MRE/MRI-PDFF SOP, validated at 8 sites",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-006", "BMK-007"]
    },
    {
      "milestone_id": "NIMBLE-2025-02",
      "consortium": "NIMBLE",
      "title": "AI digital pathology external validation (AIM-NASH)",
      "date": "2025-08-19",
      "deliverable": "AIM-NASH concordance with central pathology kappa report",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-014"]
    },
    {
      "milestone_id": "LITMUS-2025-02",
      "consortium": "LITMUS",
      "title": "LITMUS extension - Asia Pacific bridging proposal",
      "date": "2025-10-02",
      "deliverable": "KASL/JSH/APASL bridging study protocol draft",
      "korean_site_participation": true,
      "linked_biomarkers": ["BMK-021", "BMK-022", "BMK-023", "BMK-036"]
    },
    {
      "milestone_id": "NIMBLE-2025-03",
      "consortium": "NIMBLE",
      "title": "DeLIVER NIMBLE primary care external validation report",
      "date": "2025-11-15",
      "deliverable": "SHIELD model external validation in NIMBLE-DeLIVER n=1,840",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-016"]
    },
    {
      "milestone_id": "LITMUS-2026-01",
      "consortium": "LITMUS",
      "title": "LITMUS outcomes study - MALO endpoint readout",
      "date": "2026-02-28",
      "deliverable": "ProC6/PRO-C3/ELF time-to-MALO hazard analysis n=1,460",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-002", "BMK-029", "BMK-001"]
    },
    {
      "milestone_id": "NIMBLE-2026-01",
      "consortium": "NIMBLE",
      "title": "NIMBLE phase 2 launch - longitudinal cohort enrollment",
      "date": "2026-04-10",
      "deliverable": "1,200-subject longitudinal MASH cohort with paired biopsy at 0/2y",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-001", "BMK-006", "BMK-007", "BMK-014"]
    },
    {
      "milestone_id": "LITMUS-2026-02",
      "consortium": "LITMUS",
      "title": "Korean LITMUS bridging sub-study kickoff (Seoul + Busan)",
      "date": "2026-04-25",
      "deliverable": "KASL-LITMUS-Korea n=300 protocol activation",
      "korean_site_participation": true,
      "linked_biomarkers": ["BMK-021", "BMK-022", "BMK-036", "BMK-048"]
    },
    {
      "milestone_id": "NIMBLE-2026-02",
      "consortium": "NIMBLE",
      "title": "AI digital pathology + circulating biomarker fusion model",
      "date": "2026-05-08",
      "deliverable": "AIM-NASH + PRO-C3/ELF fusion classifier benchmark",
      "korean_site_participation": false,
      "linked_biomarkers": ["BMK-014", "BMK-001", "BMK-002"]
    }
  ]
}