{ "@context": { "yggdrasil": "https://example.org/yggdrasil/schema#", "label": "rdfs:label", "type": "@type" }, "@graph": [ { "@id": "yggdrasil:organ/liver", "label": "간", "type": "Organ" }, { "@id": "yggdrasil:organ/gut", "label": "장", "type": "Organ" }, { "@id": "yggdrasil:organ/adipose_visceral", "label": "내장지방", "type": "Organ" }, { "@id": "yggdrasil:organ/adipose_subcutaneous", "label": "피하지방", "type": "Organ" }, { "@id": "yggdrasil:organ/BAT", "label": "갈색지방", "type": "Organ" }, { "@id": "yggdrasil:organ/skeletal_muscle", "label": "골격근", "type": "Organ" }, { "@id": "yggdrasil:organ/bone", "label": "뼈", "type": "Organ" }, { "@id": "yggdrasil:organ/brain", "label": "뇌", "type": "Organ" }, { "@id": "yggdrasil:organ/kidney", "label": "신장", "type": "Organ" }, { "@id": "yggdrasil:organ/heart", "label": "심장", "type": "Organ" }, { "@id": "yggdrasil:organ/thyroid", "label": "갑상선", "type": "Organ" }, { "@id": "yggdrasil:organ/gonad", "label": "생식선", "type": "Organ" }, { "@id": "yggdrasil:organ/pancreas", "label": "췌장", "type": "Organ" }, { "@id": "yggdrasil:organ/immune_system", "label": "면역계", "type": "Organ" }, { "@id": "yggdrasil:organ/skin", "label": "피부", "type": "Organ" }, { "@id": "yggdrasil:mediator/FGF21", "label": "FGF21", "type": "Mediator" }, { "@id": "yggdrasil:mediator/FGF19", "label": "FGF19", "type": "Mediator" }, { "@id": "yggdrasil:mediator/GDF15", "label": "GDF15", "type": "Mediator" }, { "@id": "yggdrasil:mediator/adiponectin", "label": "아디포넥틴", "type": "Mediator" }, { "@id": "yggdrasil:mediator/leptin", "label": "렙틴", "type": "Mediator" }, { "@id": "yggdrasil:mediator/resistin", "label": "레지스틴", "type": "Mediator" }, { "@id": "yggdrasil:mediator/TNF_alpha", "label": "TNF알파", "type": "Mediator" }, { "@id": "yggdrasil:mediator/IL6", "label": "IL-6", "type": "Mediator" }, { "@id": "yggdrasil:mediator/IL17A", "label": "IL-17A", "type": "Mediator" }, { "@id": "yggdrasil:mediator/IL18", "label": "IL-18", "type": "Mediator" }, { "@id": "yggdrasil:mediator/MCP1", "label": "MCP-1", "type": "Mediator" }, { "@id": "yggdrasil:mediator/CXCL10", "label": "CXCL10", "type": "Mediator" }, { "@id": "yggdrasil:mediator/irisin", "label": "이리신", "type": "Mediator" }, { "@id": "yggdrasil:mediator/myostatin", "label": "마이오스타틴", "type": "Mediator" }, { "@id": "yggdrasil:mediator/BAIBA", "label": "BAIBA", "type": "Mediator" }, { "@id": "yggdrasil:mediator/osteocalcin", "label": "오스테오칼신", "type": "Mediator" }, { "@id": "yggdrasil:mediator/sclerostin", "label": "스클레로스틴", "type": "Mediator" }, { "@id": "yggdrasil:mediator/lipocalin2", "label": "리포칼린-2", "type": "Mediator" }, { "@id": "yggdrasil:mediator/fetuinA", "label": "페투인-A", "type": "Mediator" }, { "@id": "yggdrasil:mediator/selenoprotein_P", "label": "셀레노프로틴-P", "type": "Mediator" }, { "@id": "yggdrasil:mediator/ANGPTL4", "label": "ANGPTL4", "type": "Mediator" }, { "@id": "yggdrasil:mediator/ANGPTL8", "label": "ANGPTL8 (베타트로핀)", "type": "Mediator" }, { "@id": "yggdrasil:mediator/GLP1", "label": "GLP-1", "type": "Mediator" }, { "@id": "yggdrasil:mediator/GIP", "label": "GIP", "type": "Mediator" }, { "@id": "yggdrasil:mediator/PYY", "label": "PYY", "type": "Mediator" }, { "@id": "yggdrasil:mediator/ghrelin", "label": "그렐린", "type": "Mediator" }, { "@id": "yggdrasil:mediator/bile_acid_TCA", "label": "타우로콜산", "type": "Mediator" }, { "@id": "yggdrasil:mediator/TMAO", "label": "TMAO", "type": "Mediator" }, { "@id": "yggdrasil:mediator/indole3acetate", "label": "인돌-3-아세테이트", "type": "Mediator" }, { "@id": "yggdrasil:mediator/LPS", "label": "LPS(내독소)", "type": "Mediator" }, { "@id": "yggdrasil:mediator/SCFA_butyrate", "label": "부티르산(SCFA)", "type": "Mediator" }, { "@id": "yggdrasil:mediator/ceramide_C16", "label": "C16-세라마이드", "type": "Mediator" }, { "@id": "yggdrasil:mediator/DAG", "label": "DAG", "type": "Mediator" }, { "@id": "yggdrasil:mediator/lysoPC", "label": "lysoPC", "type": "Mediator" }, { "@id": "yggdrasil:mediator/miR122", "label": "miR-122", "type": "Mediator" }, { "@id": "yggdrasil:mediator/miR34a", "label": "miR-34a", "type": "Mediator" }, { "@id": "yggdrasil:mediator/miR103", "label": "miR-103", "type": "Mediator" }, { "@id": "yggdrasil:mediator/exosome_AdipoExos", "label": "지방세포유래 엑소좀", "type": "Mediator" }, { "@id": "yggdrasil:mediator/exosome_HepExos", "label": "간세포유래 엑소좀", "type": "Mediator" }, { "@id": "yggdrasil:mediator/BMP4", "label": "BMP4", "type": "Mediator" }, { "@id": "yggdrasil:mediator/BMP7", "label": "BMP7", "type": "Mediator" }, { "@id": "yggdrasil:mediator/T3", "label": "T3", "type": "Mediator" }, { "@id": "yggdrasil:mediator/rT3", "label": "rT3(역T3)", "type": "Mediator" }, { "@id": "yggdrasil:mediator/estradiol", "label": "에스트라디올", "type": "Mediator" }, { "@id": "yggdrasil:mediator/testosterone", "label": "테스토스테론", "type": "Mediator" }, { "@id": "yggdrasil:mediator/SHBG", "label": "SHBG", "type": "Mediator" }, { "@id": "yggdrasil:mediator/cortisol", "label": "코르티솔", "type": "Mediator" }, { "@id": "yggdrasil:mediator/insulin", "label": "인슐린", "type": "Mediator" }, { "@id": "yggdrasil:mediator/glucagon", "label": "글루카곤", "type": "Mediator" }, { "@id": "yggdrasil:mediator/amylin", "label": "아밀린", "type": "Mediator" }, { "@id": "yggdrasil:mediator/BCAA_leucine", "label": "분지쇄아미노산(루신)", "type": "Mediator" }, { "@id": "yggdrasil:mediator/kynurenine", "label": "키누레닌", "type": "Mediator" }, { "@id": "yggdrasil:mediator/lactate", "label": "락테이트", "type": "Mediator" }, { "@id": "yggdrasil:mediator/BHB", "label": "베타하이드록시부티르산", "type": "Mediator" }, { "@id": "yggdrasil:mediator/uric_acid", "label": "요산", "type": "Mediator" }, { "@id": "yggdrasil:mediator/homoarginine", "label": "호모아르기닌", "type": "Mediator" }, { "@id": "yggdrasil:mediator/FGF23", "label": "FGF23", "type": "Mediator" }, { "@id": "yggdrasil:mediator/klotho", "label": "Klotho", "type": "Mediator" }, { "@id": "yggdrasil:mediator/ANP", "label": "ANP", "type": "Mediator" }, { "@id": "yggdrasil:mediator/BNP", "label": "BNP", "type": "Mediator" }, { "@id": "yggdrasil:mediator/neuregulin4", "label": "Neuregulin-4", "type": "Mediator" }, { "@id": "yggdrasil:outcome/MASLD_steatosis", "label": "MASLD 지방증", "type": "Outcome" }, { "@id": "yggdrasil:outcome/MASH_NAS", "label": "MASH NAS≥4", "type": "Outcome" }, { "@id": "yggdrasil:outcome/fibrosis_F2", "label": "유의한 섬유화(F2)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/fibrosis_F3", "label": "진행성 섬유화(F3)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/cirrhosis_F4", "label": "간경변(F4)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/HCC", "label": "간세포암", "type": "Outcome" }, { "@id": "yggdrasil:outcome/MAFLD_resolution", "label": "MASH 해소", "type": "Outcome" }, { "@id": "yggdrasil:outcome/fibrosis_regression_1stage", "label": "섬유화 1단계 호전", "type": "Outcome" }, { "@id": "yggdrasil:outcome/ALT_normalization", "label": "ALT 정상화", "type": "Outcome" }, { "@id": "yggdrasil:outcome/MRI_PDFF_30reduction", "label": "MRI-PDFF 30%↓", "type": "Outcome" }, { "@id": "yggdrasil:outcome/MRE_stiffness", "label": "MRE 강도", "type": "Outcome" }, { "@id": "yggdrasil:outcome/FIB4", "label": "FIB-4", "type": "Outcome" }, { "@id": "yggdrasil:outcome/ELF", "label": "ELF score", "type": "Outcome" }, { "@id": "yggdrasil:outcome/Pro_C3", "label": "Pro-C3", "type": "Outcome" }, { "@id": "yggdrasil:outcome/T2DM_incident", "label": "신규 2형 당뇨병", "type": "Outcome" }, { "@id": "yggdrasil:outcome/MetS_resolution", "label": "대사증후군 해소", "type": "Outcome" }, { "@id": "yggdrasil:outcome/weight_5pct_loss", "label": "체중 5%↓", "type": "Outcome" }, { "@id": "yggdrasil:outcome/weight_10pct_loss", "label": "체중 10%↓", "type": "Outcome" }, { "@id": "yggdrasil:outcome/HbA1c_reduction", "label": "HbA1c 감소", "type": "Outcome" }, { "@id": "yggdrasil:outcome/MACE_3point", "label": "3-point MACE", "type": "Outcome" }, { "@id": "yggdrasil:outcome/HFpEF_admission", "label": "HFpEF 입원", "type": "Outcome" }, { "@id": "yggdrasil:outcome/AF_incident", "label": "신규 심방세동", "type": "Outcome" }, { "@id": "yggdrasil:outcome/stroke_ischemic", "label": "허혈성 뇌졸중", "type": "Outcome" }, { "@id": "yggdrasil:outcome/CKD_eGFR_decline", "label": "eGFR 감소(CKD)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/DKD_progression", "label": "DKD 진행", "type": "Outcome" }, { "@id": "yggdrasil:outcome/albuminuria_progression", "label": "단백뇨 진행", "type": "Outcome" }, { "@id": "yggdrasil:outcome/sarcopenia_AWGS", "label": "근감소증(AWGS)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/osteoporotic_fx", "label": "골다공증성 골절", "type": "Outcome" }, { "@id": "yggdrasil:outcome/cognitive_decline", "label": "인지기능 저하", "type": "Outcome" }, { "@id": "yggdrasil:outcome/depression_PHQ9", "label": "우울(PHQ-9)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/OSA_AHI", "label": "OSA(AHI)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/PCOS_phenotype", "label": "PCOS 표현형", "type": "Outcome" }, { "@id": "yggdrasil:outcome/hypogonadism_male", "label": "남성 성선기능저하", "type": "Outcome" }, { "@id": "yggdrasil:outcome/subclinical_hypothyroid", "label": "준임상 갑상선저하", "type": "Outcome" }, { "@id": "yggdrasil:outcome/psoriasis_PASI", "label": "건선(PASI)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/QoL_CLDQNAFLD", "label": "삶의 질(CLDQ-NAFLD)", "type": "Outcome" }, { "@id": "yggdrasil:outcome/all_cause_mortality", "label": "전원인 사망", "type": "Outcome" }, { "@id": "yggdrasil:outcome/liver_related_mortality", "label": "간관련 사망", "type": "Outcome" }, { "@id": "yggdrasil:outcome/cardiovascular_mortality", "label": "심혈관 사망", "type": "Outcome" }, { "@id": "yggdrasil:outcome/extrahepatic_cancer", "label": "간외 암(CRC/breast 등)", "type": "Outcome" }, { "@id": "yggdrasil:drug/resmetirom", "label": "레스메티롬", "type": "Drug" }, { "@id": "yggdrasil:drug/pegozafermin", "label": "페고자페르민", "type": "Drug" }, { "@id": "yggdrasil:drug/efruxifermin", "label": "에프룩시페르민", "type": "Drug" }, { "@id": "yggdrasil:drug/survodutide", "label": "수르보두타이드", "type": "Drug" }, { "@id": "yggdrasil:drug/MariTide", "label": "마리타이드", "type": "Drug" }, { "@id": "yggdrasil:drug/CagriSema", "label": "카그리세마", "type": "Drug" }, { "@id": "yggdrasil:drug/tirzepatide", "label": "티르제파타이드", "type": "Drug" }, { "@id": "yggdrasil:drug/semaglutide", "label": "세마글루타이드", "type": "Drug" }, { "@id": "yggdrasil:drug/obeticholic_acid", "label": "오베티콜릭산", "type": "Drug" }, { "@id": "yggdrasil:drug/aldafermin", "label": "알다페르민", "type": "Drug" }, { "@id": "yggdrasil:drug/lanifibranor", "label": "라니피브라노르", "type": "Drug" }, { "@id": "yggdrasil:drug/denifanstat", "label": "데니판스타트", "type": "Drug" }, { "@id": "yggdrasil:drug/SMK_3962", "label": "SMK-3962", "type": "Drug" }, { "@id": "yggdrasil:drug/tropifexor", "label": "트로피페소르", "type": "Drug" }, { "@id": "yggdrasil:drug/HPP737", "label": "HPP-737", "type": "Drug" }, { "@id": "yggdrasil:drug/VK2809", "label": "VK2809", "type": "Drug" }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_subcutaneous_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_subcutaneous", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_adipose_visceral_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/adipose_visceral", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_bone_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/bone", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_brain_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/brain", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gonad_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gonad", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_gut_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/gut", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_heart_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/heart", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_immune_system_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/immune_system", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_kidney_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/kidney", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_klotho_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_klotho_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_klotho_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_klotho_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF23_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF23_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF23_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF23_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_SHBG_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_SHBG_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_SHBG_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_SHBG_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GDF15_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GDF15_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GDF15_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GDF15_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_leptin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_leptin_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_leptin_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_leptin_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_leptin_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/leptin", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_irisin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_irisin_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_irisin_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_irisin_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_irisin_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/irisin", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_fetuinA_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_fetuinA_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_fetuinA_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_fetuinA_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_fetuinA_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/fetuinA", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_BNP_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_BNP_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_BNP_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_BNP_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_BNP_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/BNP", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF19_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF19_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF19_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF19_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF19_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF19", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_osteocalcin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_osteocalcin_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_osteocalcin_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_osteocalcin_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_osteocalcin_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/osteocalcin", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_lipocalin2_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_lipocalin2_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_lipocalin2_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_lipocalin2_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_lipocalin2_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/lipocalin2", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GLP1_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GLP1_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GLP1_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GLP1_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_GLP1_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/GLP1", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF21_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF21_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF21_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF21_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_FGF21_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/FGF21", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_adiponectin_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_adiponectin_HFpEF_admission", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/HFpEF_admission", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_adiponectin_stroke_ischemic", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/stroke_ischemic", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_adiponectin_DKD_progression", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/DKD_progression", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_liver_adiponectin_MACE_3point", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/liver", "via_mediator": "yggdrasil:mediator/adiponectin", "to_outcome": "yggdrasil:outcome/MACE_3point", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_pancreas_klotho_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/pancreas", "via_mediator": "yggdrasil:mediator/klotho", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_pancreas_FGF23_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/pancreas", "via_mediator": "yggdrasil:mediator/FGF23", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_pancreas_SHBG_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/pancreas", "via_mediator": "yggdrasil:mediator/SHBG", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 }, { "@id": "yggdrasil:tuple/BAT_pancreas_GDF15_fibrosis_F3", "type": "MASLD_4tuple_hypothesis", "source_a": "yggdrasil:organ/BAT", "source_b": "yggdrasil:organ/pancreas", "via_mediator": "yggdrasil:mediator/GDF15", "to_outcome": "yggdrasil:outcome/fibrosis_F3", "priority": 0.6779, "novelty": 1.0, "published": 0 } ], "metadata": { "source": "MASLDOrganoCrosstalk", "generated_at": "2026-05-08T13:46:00", "compatible_with": "Yggdrasil knowledge graph (mock JSON-LD)", "disclaimer": "⚠️ 디스클레이머: 이 출력은 mock 합성 데이터 기반 연구 아이디어 보조용입니다. 임상 진료에 직접 사용하지 마십시오. 실제 활용 시 PubMed/Europe PMC 원천 재검증 필수." } }