{
  "drugs": [
    {"id": "resmetirom", "name_ko": "레스메티롬", "drugbank": "DB16669", "class": "THR-beta agonist", "primary_organ": "liver", "cross_organ": ["thyroid", "heart"], "mechanism": "간 특이 TR-β 활성→DNL↓·콜레스테롤↓·미토콘드리아 산화↑"},
    {"id": "pegozafermin", "name_ko": "페고자페르민", "class": "FGF21 analog", "primary_organ": "liver", "cross_organ": ["adipose_visceral", "skeletal_muscle", "BAT"], "mechanism": "FGF21β 모방→TG↓·MASH↓·아디포넥틴↑"},
    {"id": "efruxifermin", "name_ko": "에프룩시페르민", "class": "FGF21 analog", "primary_organ": "liver", "cross_organ": ["adipose_visceral", "skeletal_muscle"], "mechanism": "FGF21 Fc 융합 다관계 작용"},
    {"id": "survodutide", "name_ko": "수르보두타이드", "class": "GLP-1/glucagon co-agonist", "primary_organ": "pancreas", "cross_organ": ["liver", "adipose_visceral", "brain"], "mechanism": "GLP-1+글루카곤→체중↓·지방산화↑·간지방↓"},
    {"id": "MariTide", "name_ko": "마리타이드", "class": "GIPR antag/GLP-1 ag", "primary_organ": "pancreas", "cross_organ": ["adipose_visceral", "liver", "brain"], "mechanism": "GIPR 차단+GLP-1→장기 체중감소"},
    {"id": "CagriSema", "name_ko": "카그리세마", "class": "Amylin+GLP-1", "primary_organ": "pancreas", "cross_organ": ["brain", "liver", "adipose_visceral"], "mechanism": "아밀린+세마→식욕↓·체중↓"},
    {"id": "tirzepatide", "name_ko": "티르제파타이드", "class": "GIP/GLP-1 dual agonist", "primary_organ": "pancreas", "cross_organ": ["liver", "adipose_visceral", "heart", "skeletal_muscle"], "mechanism": "이중 인크레틴→MASLD-T2DM-CV 통합 효과"},
    {"id": "semaglutide", "name_ko": "세마글루타이드", "class": "GLP-1 agonist", "primary_organ": "pancreas", "cross_organ": ["liver", "brain", "heart"], "mechanism": "GLP-1→체중·MASH·MACE 감소"},
    {"id": "obeticholic_acid", "name_ko": "오베티콜릭산", "class": "FXR agonist", "primary_organ": "liver", "cross_organ": ["gut", "skin"], "mechanism": "FXR→bile acid 항상성·섬유화↓(소양감 부작용)"},
    {"id": "aldafermin", "name_ko": "알다페르민", "class": "FGF19 analog", "primary_organ": "gut", "cross_organ": ["liver"], "mechanism": "FGF19 모방→bile acid 합성↓·NAS↓"},
    {"id": "lanifibranor", "name_ko": "라니피브라노르", "class": "pan-PPAR agonist", "primary_organ": "liver", "cross_organ": ["adipose_visceral", "skeletal_muscle"], "mechanism": "α/δ/γ→염증·섬유화·인슐린저항성↓"},
    {"id": "denifanstat", "name_ko": "데니판스타트", "class": "FASN inhibitor", "primary_organ": "liver", "cross_organ": ["adipose_visceral"], "mechanism": "FASN→DNL 직접 차단"},
    {"id": "SMK_3962", "name_ko": "SMK-3962", "class": "novel hepatocyte target", "primary_organ": "liver", "cross_organ": ["adipose_visceral"], "mechanism": "조사용 소분자 (mock)"},
    {"id": "tropifexor", "name_ko": "트로피페소르", "class": "FXR agonist", "primary_organ": "liver", "cross_organ": ["gut"], "mechanism": "비스테로이드 FXR"},
    {"id": "HPP737", "name_ko": "HPP-737", "class": "PDE4 modulator (mock)", "primary_organ": "liver", "cross_organ": ["immune_system", "skin"], "mechanism": "조사용 PDE4"},
    {"id": "VK2809", "name_ko": "VK2809", "class": "THR-beta agonist", "primary_organ": "liver", "cross_organ": ["thyroid"], "mechanism": "차세대 TR-β"}
  ]
}