{
  "papers": [
    {"id": "MOCK_PMID_00001", "year": 2023, "source": "PubMed", "organ_pair": ["liver", "adipose_visceral"], "mediator": "FGF21", "outcome": "MASH_NAS", "study_quality": 0.9, "n": 320},
    {"id": "MOCK_PMID_00002", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "skeletal_muscle"], "mediator": "FGF21", "outcome": "fibrosis_F2", "study_quality": 0.85, "n": 210},
    {"id": "MOCK_PMID_00003", "year": 2024, "source": "Europe PMC", "organ_pair": ["liver", "BAT"], "mediator": "FGF21", "outcome": "MRI_PDFF_30reduction", "study_quality": 0.88, "n": 180},
    {"id": "MOCK_PMID_00004", "year": 2022, "source": "PubMed", "organ_pair": ["gut", "liver"], "mediator": "FGF19", "outcome": "MAFLD_resolution", "study_quality": 0.86, "n": 240},
    {"id": "MOCK_PMID_00005", "year": 2024, "source": "PubMed", "organ_pair": ["gut", "liver"], "mediator": "LPS", "outcome": "MASH_NAS", "study_quality": 0.83, "n": 150},
    {"id": "MOCK_PMID_00006", "year": 2025, "source": "bioRxiv", "organ_pair": ["gut", "liver"], "mediator": "TMAO", "outcome": "fibrosis_F2", "study_quality": 0.7, "n": 90},
    {"id": "MOCK_PMID_00007", "year": 2023, "source": "PubMed", "organ_pair": ["gut", "adipose_visceral"], "mediator": "SCFA_butyrate", "outcome": "MetS_resolution", "study_quality": 0.82, "n": 270},
    {"id": "MOCK_PMID_00008", "year": 2024, "source": "PubMed", "organ_pair": ["adipose_visceral", "liver"], "mediator": "leptin", "outcome": "fibrosis_F3", "study_quality": 0.81, "n": 360},
    {"id": "MOCK_PMID_00009", "year": 2024, "source": "PubMed", "organ_pair": ["adipose_subcutaneous", "liver"], "mediator": "adiponectin", "outcome": "MAFLD_resolution", "study_quality": 0.88, "n": 410},
    {"id": "MOCK_PMID_00010", "year": 2023, "source": "Europe PMC", "organ_pair": ["adipose_visceral", "skeletal_muscle"], "mediator": "MCP1", "outcome": "sarcopenia_AWGS", "study_quality": 0.76, "n": 130},
    {"id": "MOCK_PMID_00011", "year": 2025, "source": "medRxiv", "organ_pair": ["adipose_visceral", "kidney"], "mediator": "exosome_AdipoExos", "outcome": "DKD_progression", "study_quality": 0.65, "n": 70},
    {"id": "MOCK_PMID_00012", "year": 2024, "source": "PubMed", "organ_pair": ["skeletal_muscle", "liver"], "mediator": "myostatin", "outcome": "fibrosis_F2", "study_quality": 0.78, "n": 200},
    {"id": "MOCK_PMID_00013", "year": 2024, "source": "PubMed", "organ_pair": ["skeletal_muscle", "liver"], "mediator": "irisin", "outcome": "MASLD_steatosis", "study_quality": 0.79, "n": 220},
    {"id": "MOCK_PMID_00014", "year": 2025, "source": "bioRxiv", "organ_pair": ["skeletal_muscle", "adipose_visceral"], "mediator": "BAIBA", "outcome": "weight_5pct_loss", "study_quality": 0.66, "n": 60},
    {"id": "MOCK_PMID_00015", "year": 2023, "source": "PubMed", "organ_pair": ["skeletal_muscle", "bone"], "mediator": "irisin", "outcome": "osteoporotic_fx", "study_quality": 0.74, "n": 140},
    {"id": "MOCK_PMID_00016", "year": 2024, "source": "PubMed", "organ_pair": ["bone", "liver"], "mediator": "osteocalcin", "outcome": "MASH_NAS", "study_quality": 0.7, "n": 110},
    {"id": "MOCK_PMID_00017", "year": 2025, "source": "medRxiv", "organ_pair": ["bone", "adipose_visceral"], "mediator": "sclerostin", "outcome": "MetS_resolution", "study_quality": 0.6, "n": 80},
    {"id": "MOCK_PMID_00018", "year": 2024, "source": "PubMed", "organ_pair": ["BAT", "liver"], "mediator": "neuregulin4", "outcome": "MASLD_steatosis", "study_quality": 0.78, "n": 95},
    {"id": "MOCK_PMID_00019", "year": 2023, "source": "PubMed", "organ_pair": ["BAT", "adipose_visceral"], "mediator": "BMP7", "outcome": "weight_5pct_loss", "study_quality": 0.72, "n": 100},
    {"id": "MOCK_PMID_00020", "year": 2024, "source": "Europe PMC", "organ_pair": ["thyroid", "liver"], "mediator": "T3", "outcome": "MAFLD_resolution", "study_quality": 0.92, "n": 510},
    {"id": "MOCK_PMID_00021", "year": 2024, "source": "PubMed", "organ_pair": ["thyroid", "liver"], "mediator": "rT3", "outcome": "fibrosis_F2", "study_quality": 0.7, "n": 120},
    {"id": "MOCK_PMID_00022", "year": 2025, "source": "ClinicalTrials.gov", "organ_pair": ["thyroid", "heart"], "mediator": "T3", "outcome": "MACE_3point", "study_quality": 0.6, "n": 0},
    {"id": "MOCK_PMID_00023", "year": 2024, "source": "PubMed", "organ_pair": ["pancreas", "liver"], "mediator": "GLP1", "outcome": "MAFLD_resolution", "study_quality": 0.94, "n": 620},
    {"id": "MOCK_PMID_00024", "year": 2024, "source": "PubMed", "organ_pair": ["pancreas", "heart"], "mediator": "GLP1", "outcome": "MACE_3point", "study_quality": 0.95, "n": 8000},
    {"id": "MOCK_PMID_00025", "year": 2024, "source": "PubMed", "organ_pair": ["pancreas", "kidney"], "mediator": "GLP1", "outcome": "albuminuria_progression", "study_quality": 0.86, "n": 700},
    {"id": "MOCK_PMID_00026", "year": 2025, "source": "bioRxiv", "organ_pair": ["pancreas", "brain"], "mediator": "GLP1", "outcome": "cognitive_decline", "study_quality": 0.66, "n": 80},
    {"id": "MOCK_PMID_00027", "year": 2024, "source": "PubMed", "organ_pair": ["heart", "liver"], "mediator": "BNP", "outcome": "HFpEF_admission", "study_quality": 0.82, "n": 540},
    {"id": "MOCK_PMID_00028", "year": 2023, "source": "PubMed", "organ_pair": ["heart", "kidney"], "mediator": "BNP", "outcome": "CKD_eGFR_decline", "study_quality": 0.78, "n": 380},
    {"id": "MOCK_PMID_00029", "year": 2024, "source": "Europe PMC", "organ_pair": ["kidney", "liver"], "mediator": "klotho", "outcome": "fibrosis_F2", "study_quality": 0.7, "n": 150},
    {"id": "MOCK_PMID_00030", "year": 2025, "source": "medRxiv", "organ_pair": ["kidney", "bone"], "mediator": "FGF23", "outcome": "osteoporotic_fx", "study_quality": 0.62, "n": 90},
    {"id": "MOCK_PMID_00031", "year": 2024, "source": "PubMed", "organ_pair": ["brain", "liver"], "mediator": "cortisol", "outcome": "MASH_NAS", "study_quality": 0.78, "n": 230},
    {"id": "MOCK_PMID_00032", "year": 2024, "source": "PubMed", "organ_pair": ["brain", "adipose_visceral"], "mediator": "leptin", "outcome": "weight_10pct_loss", "study_quality": 0.83, "n": 480},
    {"id": "MOCK_PMID_00033", "year": 2025, "source": "bioRxiv", "organ_pair": ["brain", "skeletal_muscle"], "mediator": "BCAA_leucine", "outcome": "sarcopenia_AWGS", "study_quality": 0.6, "n": 70},
    {"id": "MOCK_PMID_00034", "year": 2023, "source": "PubMed", "organ_pair": ["gonad", "liver"], "mediator": "estradiol", "outcome": "MASLD_steatosis", "study_quality": 0.88, "n": 1200},
    {"id": "MOCK_PMID_00035", "year": 2024, "source": "PubMed", "organ_pair": ["gonad", "liver"], "mediator": "testosterone", "outcome": "MAFLD_resolution", "study_quality": 0.75, "n": 320},
    {"id": "MOCK_PMID_00036", "year": 2024, "source": "PubMed", "organ_pair": ["gonad", "adipose_visceral"], "mediator": "SHBG", "outcome": "MetS_resolution", "study_quality": 0.83, "n": 950},
    {"id": "MOCK_PMID_00037", "year": 2025, "source": "medRxiv", "organ_pair": ["immune_system", "liver"], "mediator": "IL17A", "outcome": "MASH_NAS", "study_quality": 0.7, "n": 130},
    {"id": "MOCK_PMID_00038", "year": 2024, "source": "PubMed", "organ_pair": ["immune_system", "liver"], "mediator": "TNF_alpha", "outcome": "fibrosis_F3", "study_quality": 0.84, "n": 410},
    {"id": "MOCK_PMID_00039", "year": 2024, "source": "PubMed", "organ_pair": ["immune_system", "adipose_visceral"], "mediator": "IL18", "outcome": "MetS_resolution", "study_quality": 0.7, "n": 240},
    {"id": "MOCK_PMID_00040", "year": 2024, "source": "PubMed", "organ_pair": ["skin", "liver"], "mediator": "IL17A", "outcome": "psoriasis_PASI", "study_quality": 0.78, "n": 320},
    {"id": "MOCK_PMID_00041", "year": 2025, "source": "WHO_ICTRP", "organ_pair": ["liver", "kidney"], "mediator": "selenoprotein_P", "outcome": "DKD_progression", "study_quality": 0.55, "n": 0},
    {"id": "MOCK_PMID_00042", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "heart"], "mediator": "fetuinA", "outcome": "MACE_3point", "study_quality": 0.78, "n": 620},
    {"id": "MOCK_PMID_00043", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "kidney"], "mediator": "lipocalin2", "outcome": "CKD_eGFR_decline", "study_quality": 0.74, "n": 280},
    {"id": "MOCK_PMID_00044", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "brain"], "mediator": "kynurenine", "outcome": "depression_PHQ9", "study_quality": 0.65, "n": 110},
    {"id": "MOCK_PMID_00045", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "brain"], "mediator": "ANGPTL4", "outcome": "cognitive_decline", "study_quality": 0.6, "n": 80},
    {"id": "MOCK_PMID_00046", "year": 2023, "source": "PubMed", "organ_pair": ["adipose_visceral", "heart"], "mediator": "leptin", "outcome": "AF_incident", "study_quality": 0.78, "n": 540},
    {"id": "MOCK_PMID_00047", "year": 2024, "source": "PubMed", "organ_pair": ["adipose_visceral", "brain"], "mediator": "exosome_AdipoExos", "outcome": "cognitive_decline", "study_quality": 0.62, "n": 90},
    {"id": "MOCK_PMID_00048", "year": 2025, "source": "ClinicalTrials.gov", "organ_pair": ["liver", "skeletal_muscle"], "mediator": "irisin", "outcome": "sarcopenia_AWGS", "study_quality": 0.55, "n": 0},
    {"id": "MOCK_PMID_00049", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "thyroid"], "mediator": "rT3", "outcome": "subclinical_hypothyroid", "study_quality": 0.7, "n": 200},
    {"id": "MOCK_PMID_00050", "year": 2024, "source": "PubMed", "organ_pair": ["pancreas", "skeletal_muscle"], "mediator": "insulin", "outcome": "sarcopenia_AWGS", "study_quality": 0.74, "n": 180},
    {"id": "MOCK_PMID_00051", "year": 2024, "source": "PubMed", "organ_pair": ["bone", "kidney"], "mediator": "FGF23", "outcome": "CKD_eGFR_decline", "study_quality": 0.81, "n": 420},
    {"id": "MOCK_PMID_00052", "year": 2024, "source": "PubMed", "organ_pair": ["heart", "brain"], "mediator": "BNP", "outcome": "stroke_ischemic", "study_quality": 0.83, "n": 700},
    {"id": "MOCK_PMID_00053", "year": 2025, "source": "bioRxiv", "organ_pair": ["liver", "gonad"], "mediator": "SHBG", "outcome": "PCOS_phenotype", "study_quality": 0.65, "n": 90},
    {"id": "MOCK_PMID_00054", "year": 2025, "source": "medRxiv", "organ_pair": ["liver", "immune_system"], "mediator": "CXCL10", "outcome": "fibrosis_F3", "study_quality": 0.7, "n": 100},
    {"id": "MOCK_PMID_00055", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "adipose_visceral"], "mediator": "ANGPTL8", "outcome": "MASLD_steatosis", "study_quality": 0.68, "n": 130},
    {"id": "MOCK_PMID_00056", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "skeletal_muscle"], "mediator": "ceramide_C16", "outcome": "fibrosis_F2", "study_quality": 0.72, "n": 160},
    {"id": "MOCK_PMID_00057", "year": 2024, "source": "PubMed", "organ_pair": ["adipose_visceral", "bone"], "mediator": "sclerostin", "outcome": "osteoporotic_fx", "study_quality": 0.7, "n": 200},
    {"id": "MOCK_PMID_00058", "year": 2024, "source": "PubMed", "organ_pair": ["BAT", "skeletal_muscle"], "mediator": "neuregulin4", "outcome": "sarcopenia_AWGS", "study_quality": 0.6, "n": 70},
    {"id": "MOCK_PMID_00059", "year": 2025, "source": "WHO_ICTRP", "organ_pair": ["gut", "skin"], "mediator": "LPS", "outcome": "psoriasis_PASI", "study_quality": 0.55, "n": 0},
    {"id": "MOCK_PMID_00060", "year": 2024, "source": "PubMed", "organ_pair": ["pancreas", "bone"], "mediator": "amylin", "outcome": "osteoporotic_fx", "study_quality": 0.62, "n": 110},
    {"id": "MOCK_PMID_00061", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "heart"], "mediator": "uric_acid", "outcome": "HFpEF_admission", "study_quality": 0.7, "n": 240},
    {"id": "MOCK_PMID_00062", "year": 2025, "source": "bioRxiv", "organ_pair": ["liver", "extrahepatic"], "mediator": "miR122", "outcome": "extrahepatic_cancer", "study_quality": 0.6, "n": 80},
    {"id": "MOCK_PMID_00063", "year": 2024, "source": "PubMed", "organ_pair": ["adipose_visceral", "gonad"], "mediator": "resistin", "outcome": "PCOS_phenotype", "study_quality": 0.65, "n": 120},
    {"id": "MOCK_PMID_00064", "year": 2024, "source": "PubMed", "organ_pair": ["skeletal_muscle", "kidney"], "mediator": "BCAA_leucine", "outcome": "DKD_progression", "study_quality": 0.66, "n": 140},
    {"id": "MOCK_PMID_00065", "year": 2025, "source": "medRxiv", "organ_pair": ["BAT", "heart"], "mediator": "neuregulin4", "outcome": "HFpEF_admission", "study_quality": 0.6, "n": 80},
    {"id": "MOCK_PMID_00066", "year": 2024, "source": "PubMed", "organ_pair": ["adipose_visceral", "liver"], "mediator": "TNF_alpha", "outcome": "MASH_NAS", "study_quality": 0.85, "n": 380},
    {"id": "MOCK_PMID_00067", "year": 2024, "source": "PubMed", "organ_pair": ["adipose_visceral", "liver"], "mediator": "IL6", "outcome": "fibrosis_F2", "study_quality": 0.78, "n": 290},
    {"id": "MOCK_PMID_00068", "year": 2024, "source": "PubMed", "organ_pair": ["gut", "brain"], "mediator": "indole3acetate", "outcome": "depression_PHQ9", "study_quality": 0.65, "n": 100},
    {"id": "MOCK_PMID_00069", "year": 2025, "source": "bioRxiv", "organ_pair": ["gut", "skeletal_muscle"], "mediator": "SCFA_butyrate", "outcome": "sarcopenia_AWGS", "study_quality": 0.62, "n": 80},
    {"id": "MOCK_PMID_00070", "year": 2024, "source": "PubMed", "organ_pair": ["liver", "QoL"], "mediator": "GDF15", "outcome": "QoL_CLDQNAFLD", "study_quality": 0.68, "n": 150}
  ]
}