{
  "_note": "Mediation pathway 5종 + surrogate marker. VanderWeele 2014 / Imai-Keele-Tingley 분석 권고.",
  "mediations": [
    {
      "id": "weight_loss",
      "name": "Weight loss pathway",
      "surrogate": "% TBWL (W12, W24, W52)",
      "analysis_model": "natural direct/indirect effect (Imai-Keele-Tingley)",
      "min_separable_effect_pct": 30
    },
    {
      "id": "glucose",
      "name": "Glycemic control pathway",
      "surrogate": "ΔHbA1c, fasting glucose",
      "analysis_model": "VanderWeele mediation (continuous mediator)",
      "min_separable_effect_pct": 20
    },
    {
      "id": "anti_inflammatory_direct",
      "name": "Direct anti-inflammatory / pleiotropic",
      "surrogate": "hs-CRP, IL-6, GDF-15",
      "analysis_model": "weight-adjusted residual analysis + sensitivity",
      "min_separable_effect_pct": 15
    },
    {
      "id": "natriuresis",
      "name": "Natriuresis / volume",
      "surrogate": "NT-proBNP, eGFR, BP, urinary Na",
      "analysis_model": "longitudinal mediation, repeated measure",
      "min_separable_effect_pct": 25
    },
    {
      "id": "autonomic",
      "name": "Autonomic / heart rate / HRV",
      "surrogate": "resting HR, HRV (SDNN, RMSSD)",
      "analysis_model": "time-varying mediator model",
      "min_separable_effect_pct": 10
    }
  ]
}