{
  "snps": [
    {
      "id": "PNPLA3_rs738409",
      "gene": "PNPLA3",
      "rsid": "rs738409",
      "risk_allele": "G",
      "function": "I148M missense; loss of TG hydrolase activity",
      "ethnic_freq": {"East_Asian": 0.42, "Caucasian": 0.23, "African": 0.13},
      "phenotype": "Steatosis, MASH, fibrosis, HCC; lean MASLD signal in East Asian"
    },
    {
      "id": "TM6SF2_rs58542926",
      "gene": "TM6SF2",
      "rsid": "rs58542926",
      "risk_allele": "T",
      "function": "E167K missense; impaired VLDL secretion",
      "ethnic_freq": {"East_Asian": 0.04, "Caucasian": 0.075, "African": 0.02},
      "phenotype": "Steatosis, fibrosis, lower CV risk"
    },
    {
      "id": "HSD17B13_rs72613567",
      "gene": "HSD17B13",
      "rsid": "rs72613567",
      "risk_allele": "TA_insertion",
      "function": "Splice variant; loss of function",
      "ethnic_freq": {"East_Asian": 0.34, "Caucasian": 0.26, "African": 0.07},
      "phenotype": "Protective for MASH and fibrosis"
    },
    {
      "id": "MBOAT7_rs641738",
      "gene": "MBOAT7",
      "rsid": "rs641738",
      "risk_allele": "T",
      "function": "Decreased MBOAT7 expression; altered PI remodeling",
      "ethnic_freq": {"East_Asian": 0.45, "Caucasian": 0.43, "African": 0.18},
      "phenotype": "Steatosis, fibrosis (modest)"
    },
    {
      "id": "GCKR_rs1260326",
      "gene": "GCKR",
      "rsid": "rs1260326",
      "risk_allele": "T",
      "function": "P446L; reduced GKRP inhibition of GCK",
      "ethnic_freq": {"East_Asian": 0.51, "Caucasian": 0.41, "African": 0.11},
      "phenotype": "Steatosis, hypertriglyceridemia"
    }
  ]
}