{
  "_note": "All evidence values are SYNTHETIC for offline demo. Do NOT cite as real PubMed counts.",
  "pubmed_counts": {
    "PNPLA3_rs738409__resmetirom": 7,
    "PNPLA3_rs738409__semaglutide": 4,
    "PNPLA3_rs738409__pioglitazone": 12,
    "PNPLA3_rs738409__vitamin_E": 9,
    "TM6SF2_rs58542926__resmetirom": 1,
    "TM6SF2_rs58542926__lanifibranor": 0,
    "HSD17B13_rs72613567__efruxifermin": 0,
    "HSD17B13_rs72613567__pegozafermin": 0,
    "MBOAT7_rs641738__semaglutide": 1,
    "GCKR_rs1260326__tirzepatide": 0,
    "GCKR_rs1260326__semaglutide": 2
  },
  "gwas_supporting": {
    "PNPLA3_rs738409": ["steatosis", "MASH", "fibrosis", "HCC"],
    "TM6SF2_rs58542926": ["steatosis", "fibrosis"],
    "HSD17B13_rs72613567": ["protective_MASH", "protective_HCC"],
    "MBOAT7_rs641738": ["steatosis"],
    "GCKR_rs1260326": ["TG", "steatosis"]
  },
  "trial_stratification": {
    "resmetirom__MAESTRO_NASH": {"PNPLA3": false, "TM6SF2": false, "HSD17B13": false},
    "efruxifermin__SYMMETRY": {"PNPLA3": false, "TM6SF2": false, "HSD17B13": false},
    "pegozafermin__ENLIVEN": {"PNPLA3": false, "TM6SF2": false, "HSD17B13": false},
    "lanifibranor__NATIV3": {"PNPLA3": false, "TM6SF2": false, "HSD17B13": false},
    "semaglutide__ESSENCE": {"PNPLA3": false, "TM6SF2": false, "HSD17B13": false},
    "tirzepatide__SYNERGY_NASH": {"PNPLA3": false, "TM6SF2": false, "HSD17B13": false},
    "survodutide__MASH_PHASE2": {"PNPLA3": false, "TM6SF2": false, "HSD17B13": false}
  },
  "mechanism_plausibility": {
    "PNPLA3_rs738409__resmetirom": 0.85,
    "PNPLA3_rs738409__efruxifermin": 0.80,
    "PNPLA3_rs738409__pegozafermin": 0.78,
    "PNPLA3_rs738409__lanifibranor": 0.72,
    "PNPLA3_rs738409__semaglutide": 0.50,
    "PNPLA3_rs738409__tirzepatide": 0.55,
    "PNPLA3_rs738409__survodutide": 0.65,
    "PNPLA3_rs738409__pioglitazone": 0.60,
    "PNPLA3_rs738409__vitamin_E": 0.55,
    "TM6SF2_rs58542926__resmetirom": 0.80,
    "TM6SF2_rs58542926__efruxifermin": 0.82,
    "TM6SF2_rs58542926__pegozafermin": 0.80,
    "TM6SF2_rs58542926__lanifibranor": 0.70,
    "TM6SF2_rs58542926__semaglutide": 0.45,
    "TM6SF2_rs58542926__tirzepatide": 0.48,
    "HSD17B13_rs72613567__resmetirom": 0.62,
    "HSD17B13_rs72613567__efruxifermin": 0.70,
    "HSD17B13_rs72613567__pegozafermin": 0.68,
    "HSD17B13_rs72613567__lanifibranor": 0.65,
    "HSD17B13_rs72613567__semaglutide": 0.40,
    "MBOAT7_rs641738__resmetirom": 0.55,
    "MBOAT7_rs641738__efruxifermin": 0.60,
    "MBOAT7_rs641738__lanifibranor": 0.58,
    "MBOAT7_rs641738__semaglutide": 0.45,
    "GCKR_rs1260326__resmetirom": 0.58,
    "GCKR_rs1260326__efruxifermin": 0.62,
    "GCKR_rs1260326__semaglutide": 0.55,
    "GCKR_rs1260326__tirzepatide": 0.60
  },
  "korean_lean_cohort_n_estimate": {
    "PNPLA3_rs738409__GG_or_CG": 1800,
    "PNPLA3_rs738409__GG_only": 320,
    "TM6SF2_rs58542926__minor_carrier": 110,
    "HSD17B13_rs72613567__protective_carrier": 950,
    "MBOAT7_rs641738__minor": 1500,
    "GCKR_rs1260326__minor": 1700
  }
}