{
  "_note": "Synthetic FAERS PRR/ROR signals. NOT real FAERS data. For demonstration only.",
  "_seed": 20260501,
  "drug_class_signals": {
    "SGLT2i": {"euglycemic_DKA_PRR": 4.8, "lower_limb_amp_ROR": 1.7, "AKI_PRR": 0.9},
    "GLP1RA": {"pancreatitis_PRR": 1.6, "thyroid_C-cell_ROR": 1.3, "AKI_PRR": 1.1},
    "MRA": {"hyperkalemia_PRR": 6.2, "AKI_PRR": 1.4, "gynecomastia_ROR": 3.1},
    "RAS": {"hyperkalemia_PRR": 3.8, "AKI_PRR": 1.9, "angioedema_ROR": 2.4},
    "ADJ": {"infection_PRR": 2.1, "thrombosis_ROR": 1.8, "hepatotoxicity_PRR": 1.5}
  },
  "combo_synergy_caution": [
    {"combo": ["MRA","RAS"], "issue": "hyperkalemia synergy", "weight": 0.7},
    {"combo": ["SGLT2i","GLP1RA"], "issue": "GI/volume contraction", "weight": 0.3},
    {"combo": ["SGLT2i","MRA"], "issue": "diuretic excess in HF", "weight": 0.4},
    {"combo": ["MRA","ADJ"], "issue": "immune+electrolyte", "weight": 0.5}
  ]
}