{
  "snapshot_date": "2026-04-26",
  "source": "synthetic_clinicaltrials_gov_v2",
  "trials": [
    {
      "nct_id": "NCT09000101",
      "title": "Resmetirom Long-Term Outcomes in MASH F2-F3 (synthetic)",
      "phase": "Phase 3",
      "status": "Recruiting",
      "sponsor": "Madrigal",
      "drug": "resmetirom",
      "mechanism": "THR-beta",
      "primary_completion": "2027-06",
      "results_posted": false,
      "ae_terms": ["diarrhea", "nausea"]
    },
    {
      "nct_id": "NCT09000102",
      "title": "Efruxifermin SYMMETRY-Like Cirrhotic MASH (synthetic)",
      "phase": "Phase 3",
      "status": "Recruiting",
      "sponsor": "Akero",
      "drug": "efruxifermin",
      "mechanism": "FGF21",
      "primary_completion": "2027-09",
      "results_posted": false,
      "ae_terms": ["injection-site reaction", "diarrhea", "transient ALT elevation"]
    },
    {
      "nct_id": "NCT09000103",
      "title": "Pegozafermin ENLIGHTEN-Synth in F4 MASH (synthetic)",
      "phase": "Phase 3",
      "status": "Recruiting",
      "sponsor": "89bio",
      "drug": "pegozafermin",
      "mechanism": "FGF21",
      "primary_completion": "2028-03",
      "results_posted": false,
      "ae_terms": ["nausea", "injection-site reaction"]
    },
    {
      "nct_id": "NCT09000104",
      "title": "Survodutide MASH F2-F3 dose-finding (synthetic)",
      "phase": "Phase 3",
      "status": "Recruiting",
      "sponsor": "Boehringer",
      "drug": "survodutide",
      "mechanism": "GCG-GLP",
      "primary_completion": "2027-11",
      "results_posted": false,
      "ae_terms": ["nausea", "vomiting"]
    },
    {
      "nct_id": "NCT09000105",
      "title": "Pemvidutide IMPACT-Synth MASH (synthetic)",
      "phase": "Phase 2b",
      "status": "Completed",
      "sponsor": "Altimmune",
      "drug": "pemvidutide",
      "mechanism": "GCG-GLP",
      "primary_completion": "2026-05",
      "results_posted": true,
      "ae_terms": ["nausea", "decreased appetite", "transient lipase elevation"]
    },
    {
      "nct_id": "NCT09000106",
      "title": "Lanifibranor NATIV3-Synth (synthetic)",
      "phase": "Phase 3",
      "status": "Recruiting",
      "sponsor": "Inventiva",
      "drug": "lanifibranor",
      "mechanism": "PPAR",
      "primary_completion": "2027-04",
      "results_posted": false,
      "ae_terms": ["weight gain", "edema"]
    },
    {
      "nct_id": "NCT09000107",
      "title": "Denifanstat FASCINATE-Synth in MASH F2-F3 (synthetic)",
      "phase": "Phase 3",
      "status": "Recruiting",
      "sponsor": "Sagimet",
      "drug": "denifanstat",
      "mechanism": "FASN",
      "primary_completion": "2027-08",
      "results_posted": false,
      "ae_terms": ["alopecia", "dry skin"]
    },
    {
      "nct_id": "NCT09000108",
      "title": "Aldafermin ALPINE-Synth (synthetic)",
      "phase": "Phase 2b",
      "status": "Completed",
      "sponsor": "NGM Bio",
      "drug": "aldafermin",
      "mechanism": "FGF19",
      "primary_completion": "2025-12",
      "results_posted": true,
      "ae_terms": ["diarrhea"]
    },
    {
      "nct_id": "NCT09000109",
      "title": "Vonafexor LIVIFY-Synth FXR (synthetic)",
      "phase": "Phase 2",
      "status": "Recruiting",
      "sponsor": "Enyo",
      "drug": "vonafexor",
      "mechanism": "FXR",
      "primary_completion": "2026-10",
      "results_posted": false,
      "ae_terms": ["pruritus"]
    },
    {
      "nct_id": "NCT09000110",
      "title": "Tirzepatide SYNERGY-NASH-Synth (synthetic)",
      "phase": "Phase 3",
      "status": "Active, not recruiting",
      "sponsor": "Eli Lilly",
      "drug": "tirzepatide",
      "mechanism": "GIP-GLP",
      "primary_completion": "2026-08",
      "results_posted": false,
      "ae_terms": ["nausea", "diarrhea"]
    },
    {
      "nct_id": "NCT09000111",
      "title": "Semaglutide ESSENCE-Synth MASH F2-F3 (synthetic)",
      "phase": "Phase 3",
      "status": "Completed",
      "sponsor": "Novo Nordisk",
      "drug": "semaglutide-2.4",
      "mechanism": "GLP-1",
      "primary_completion": "2026-04",
      "results_posted": true,
      "ae_terms": ["nausea", "vomiting", "constipation"]
    },
    {
      "nct_id": "NCT09000112",
      "title": "Ervogastat DGAT2 + ACC combo MASH (synthetic)",
      "phase": "Phase 2",
      "status": "Recruiting",
      "sponsor": "Pfizer",
      "drug": "ervogastat",
      "mechanism": "DGAT2",
      "primary_completion": "2026-12",
      "results_posted": false,
      "ae_terms": ["hypertriglyceridemia"]
    },
    {
      "nct_id": "NCT09000113",
      "title": "Retatrutide TRIUMPH-MASH-Synth Phase 2 (synthetic)",
      "phase": "Phase 2",
      "status": "Recruiting",
      "sponsor": "Eli Lilly",
      "drug": "retatrutide",
      "mechanism": "GIP-GLP-GCG",
      "primary_completion": "2027-09",
      "results_posted": false,
      "ae_terms": ["nausea", "vomiting"]
    },
    {
      "nct_id": "NCT09000114",
      "title": "VK2809 VOYAGE-Synth MASH F2-F3 (synthetic)",
      "phase": "Phase 2b",
      "status": "Recruiting",
      "sponsor": "Viking",
      "drug": "VK2809",
      "mechanism": "THR-beta",
      "primary_completion": "2027-02",
      "results_posted": false,
      "ae_terms": ["diarrhea"]
    }
  ]
}