"""Obesity drug vocabulary, target receptor, sponsor mapping. NOTE: 본 vocabulary는 공개적으로 알려진 비만 파이프라인 약물명을 참조용으로 정리한 것이며, 임상 권고나 처방 근거가 아닙니다. 모든 매핑은 합성·교육용입니다. """ # Active obesity pipeline drug vocabulary (50+ entries). # Each entry: canonical name, list of aliases, list of receptor targets, sponsor. DRUG_VOCAB = [ # GLP-1 receptor agonists {"canonical": "semaglutide", "aliases": ["semaglutide", "Wegovy", "Ozempic", "NN9535"], "targets": ["GLP-1"], "sponsor": "Novo Nordisk"}, {"canonical": "oral semaglutide", "aliases": ["oral semaglutide", "Rybelsus", "PIONEER-PLUS"], "targets": ["GLP-1"], "sponsor": "Novo Nordisk"}, {"canonical": "liraglutide", "aliases": ["liraglutide", "Saxenda", "Victoza"], "targets": ["GLP-1"], "sponsor": "Novo Nordisk"}, {"canonical": "orforglipron", "aliases": ["orforglipron", "LY3502970"], "targets": ["GLP-1"], "sponsor": "Eli Lilly"}, {"canonical": "danuglipron", "aliases": ["danuglipron", "PF-06882961"], "targets": ["GLP-1"], "sponsor": "Pfizer"}, {"canonical": "ecnoglutide", "aliases": ["ecnoglutide", "XW003"], "targets": ["GLP-1"], "sponsor": "Sciwind Biosciences"}, {"canonical": "noiiglutide", "aliases": ["noiiglutide", "HRS9531-mono"], "targets": ["GLP-1"], "sponsor": "Hengrui Pharma"}, # GLP-1 / GIP dual agonists {"canonical": "tirzepatide", "aliases": ["tirzepatide", "Mounjaro", "Zepbound", "LY3298176"], "targets": ["GLP-1", "GIP"], "sponsor": "Eli Lilly"}, {"canonical": "MariTide", "aliases": ["MariTide", "AMG 133", "maridebart cafraglutide"], "targets": ["GLP-1", "GIP"], "sponsor": "Amgen"}, {"canonical": "CT-388", "aliases": ["CT-388"], "targets": ["GLP-1", "GIP"], "sponsor": "Carmot Therapeutics"}, {"canonical": "VK2735", "aliases": ["VK2735"], "targets": ["GLP-1", "GIP"], "sponsor": "Viking Therapeutics"}, # GLP-1 / glucagon dual {"canonical": "survodutide", "aliases": ["survodutide", "BI 456906"], "targets": ["GLP-1", "Glucagon"], "sponsor": "Boehringer Ingelheim / Zealand"}, {"canonical": "mazdutide", "aliases": ["mazdutide", "IBI362", "LY3305677"], "targets": ["GLP-1", "Glucagon"], "sponsor": "Innovent / Eli Lilly"}, {"canonical": "pemvidutide", "aliases": ["pemvidutide", "ALT-801"], "targets": ["GLP-1", "Glucagon"], "sponsor": "Altimmune"}, {"canonical": "efinopegdutide", "aliases": ["efinopegdutide", "MK-6024", "HM12525A"], "targets": ["GLP-1", "Glucagon"], "sponsor": "Merck / Hanmi"}, {"canonical": "cotadutide", "aliases": ["cotadutide", "MEDI0382"], "targets": ["GLP-1", "Glucagon"], "sponsor": "AstraZeneca"}, # GLP-1 / GIP / glucagon triple {"canonical": "retatrutide", "aliases": ["retatrutide", "LY3437943"], "targets": ["GLP-1", "GIP", "Glucagon"], "sponsor": "Eli Lilly"}, {"canonical": "HM15211", "aliases": ["HM15211", "efocipegtrutide"], "targets": ["GLP-1", "GIP", "Glucagon"], "sponsor": "Hanmi"}, # Amylin and amylin combos {"canonical": "cagrilintide", "aliases": ["cagrilintide", "AM833"], "targets": ["Amylin"], "sponsor": "Novo Nordisk"}, {"canonical": "CagriSema", "aliases": ["CagriSema", "cagrilintide+semaglutide"], "targets": ["Amylin", "GLP-1"], "sponsor": "Novo Nordisk"}, {"canonical": "petrelintide", "aliases": ["petrelintide", "ZP8396"], "targets": ["Amylin"], "sponsor": "Zealand Pharma"}, {"canonical": "amycretin", "aliases": ["amycretin", "NN9487"], "targets": ["Amylin", "GLP-1"], "sponsor": "Novo Nordisk"}, # MC4R / leptin / FGF {"canonical": "setmelanotide", "aliases": ["setmelanotide", "Imcivree", "RM-493"], "targets": ["MC4R"], "sponsor": "Rhythm Pharmaceuticals"}, {"canonical": "bivamelagon", "aliases": ["bivamelagon", "LB54640"], "targets": ["MC4R"], "sponsor": "LG Chem / Rhythm"}, {"canonical": "metreleptin", "aliases": ["metreleptin", "Myalept"], "targets": ["Leptin"], "sponsor": "Amryt / Chiesi"}, {"canonical": "mibavademab", "aliases": ["mibavademab", "REGN4461"], "targets": ["LepR"], "sponsor": "Regeneron"}, {"canonical": "efruxifermin", "aliases": ["efruxifermin", "EFX"], "targets": ["FGF21"], "sponsor": "Akero Therapeutics"}, {"canonical": "pegozafermin", "aliases": ["pegozafermin", "BIO89-100"], "targets": ["FGF21"], "sponsor": "89bio"}, # Other mechanisms {"canonical": "bimagrumab", "aliases": ["bimagrumab", "BYM338"], "targets": ["ActRII"], "sponsor": "Versanis / Eli Lilly"}, {"canonical": "GSBR-1290", "aliases": ["GSBR-1290"], "targets": ["GLP-1"], "sponsor": "Structure Therapeutics"}, {"canonical": "ARD-101", "aliases": ["ARD-101"], "targets": ["TAS2R"], "sponsor": "Aardvark Therapeutics"}, {"canonical": "ARD-201", "aliases": ["ARD-201"], "targets": ["TAS2R", "DPP-4"], "sponsor": "Aardvark Therapeutics"}, {"canonical": "naltrexone-bupropion", "aliases": ["naltrexone-bupropion", "Contrave", "Mysimba"], "targets": ["MOR", "DAT"], "sponsor": "Currax Pharmaceuticals"}, {"canonical": "phentermine-topiramate", "aliases": ["phentermine-topiramate", "Qsymia"], "targets": ["NA", "GABA"], "sponsor": "Vivus"}, {"canonical": "tesofensine", "aliases": ["tesofensine"], "targets": ["MAT"], "sponsor": "Saniona"}, {"canonical": "olezarsen", "aliases": ["olezarsen"], "targets": ["APOC3"], "sponsor": "Ionis"}, {"canonical": "evexomostat", "aliases": ["evexomostat", "SDX-7320"], "targets": ["MetAP2"], "sponsor": "SynDevRx"}, {"canonical": "beloranib", "aliases": ["beloranib", "ZGN-433"], "targets": ["MetAP2"], "sponsor": "Zafgen (legacy)"}, {"canonical": "lipocalin-2-mAb", "aliases": ["lipocalin-2-mAb", "LCN2-mAb"], "targets": ["LCN2"], "sponsor": "Academic"}, # Newer combinations / add-ons {"canonical": "tirzepatide+bimagrumab", "aliases": ["tirzepatide+bimagrumab"], "targets": ["GLP-1", "GIP", "ActRII"], "sponsor": "Eli Lilly"}, {"canonical": "semaglutide+cagrilintide", "aliases": ["semaglutide+cagrilintide"], "targets": ["GLP-1", "Amylin"], "sponsor": "Novo Nordisk"}, {"canonical": "retatrutide+SGLT2i", "aliases": ["retatrutide+SGLT2i"], "targets": ["GLP-1", "GIP", "Glucagon", "SGLT2"], "sponsor": "Academic combo"}, {"canonical": "HRS9531", "aliases": ["HRS9531"], "targets": ["GLP-1", "GIP"], "sponsor": "Hengrui Pharma"}, {"canonical": "XW014", "aliases": ["XW014"], "targets": ["GLP-1"], "sponsor": "Sciwind Biosciences"}, {"canonical": "DA-1726", "aliases": ["DA-1726"], "targets": ["GLP-1", "Glucagon"], "sponsor": "NeuroBo / Dong-A"}, {"canonical": "DD01", "aliases": ["DD01"], "targets": ["GLP-1", "Glucagon"], "sponsor": "Neuraly / D&D Pharmatech"}, {"canonical": "GLY-200", "aliases": ["GLY-200"], "targets": ["GutBarrier"], "sponsor": "Glyscend"}, {"canonical": "MET-097i", "aliases": ["MET-097i"], "targets": ["GLP-1"], "sponsor": "Metsera"}, {"canonical": "ASC30", "aliases": ["ASC30"], "targets": ["GLP-1"], "sponsor": "Ascletis"}, {"canonical": "TERN-601", "aliases": ["TERN-601"], "targets": ["GLP-1"], "sponsor": "Terns Pharmaceuticals"}, {"canonical": "ECC5004", "aliases": ["ECC5004"], "targets": ["GLP-1"], "sponsor": "Eccogene / AstraZeneca"}, ] # Receptor → human-readable label RECEPTOR_LABELS = { "GLP-1": "GLP-1 receptor", "GIP": "GIP receptor", "Glucagon": "Glucagon receptor", "Amylin": "Amylin receptor (CTR/RAMP)", "MC4R": "Melanocortin-4 receptor", "Leptin": "Leptin", "LepR": "Leptin receptor", "FGF21": "FGF21", "ActRII": "Activin type II receptor", "TAS2R": "Bitter taste receptor", "DPP-4": "DPP-4", "MOR": "Mu-opioid receptor", "DAT": "Dopamine transporter", "NA": "Noradrenergic", "GABA": "GABAergic", "MAT": "Monoamine transporter", "APOC3": "Apolipoprotein C-III", "MetAP2": "Methionine aminopeptidase 2", "LCN2": "Lipocalin-2", "SGLT2": "SGLT2", "GutBarrier": "Gut barrier modulator", } def all_aliases(): """Return list of (alias_lower, canonical) for matching.""" out = [] for entry in DRUG_VOCAB: for alias in entry["aliases"]: out.append((alias.lower(), entry["canonical"])) # Sort longest-first to match longer aliases before shorter substrings. out.sort(key=lambda x: -len(x[0])) return out def lookup(canonical): """Look up vocab entry by canonical name.""" for entry in DRUG_VOCAB: if entry["canonical"] == canonical: return entry return None def total_drug_count(): return len(DRUG_VOCAB)