{
  "_note": "Synthetic Reactome-style pathway mapping per myokine. Used for mechanism non-overlap scoring.",
  "myokine_to_pathways": {
    "myostatin": ["R-HSA-TGF_BETA_SIGNALING", "R-HSA-SMAD2_3", "R-HSA-MUSCLE_ATROPHY"],
    "FGF21": ["R-HSA-FGF_SIGNALING", "R-HSA-AMPK", "R-HSA-PPAR_ALPHA", "R-HSA-LIPOLYSIS"],
    "GDF15": ["R-HSA-GFRAL_SIGNALING", "R-HSA-INTEGRATED_STRESS_RESPONSE", "R-HSA-MITOCHONDRIAL_STRESS"],
    "irisin": ["R-HSA-UCP1_BROWNING", "R-HSA-AMPK", "R-HSA-PGC1A"],
    "IL-6": ["R-HSA-JAK_STAT", "R-HSA-IL6_SIGNALING", "R-HSA-ACUTE_PHASE"],
    "BAIBA": ["R-HSA-AMPK", "R-HSA-UCP1_BROWNING", "R-HSA-FATTY_ACID_OXIDATION"],
    "METRNL": ["R-HSA-EOSINOPHIL_IL4", "R-HSA-UCP1_BROWNING", "R-HSA-PGC1A"],
    "SPARC": ["R-HSA-ECM_ORGANIZATION", "R-HSA-COLLAGEN_FORMATION", "R-HSA-INTEGRIN"],
    "IGF-1": ["R-HSA-PI3K_AKT", "R-HSA-MTOR", "R-HSA-PROTEIN_SYNTHESIS"],
    "IL-15": ["R-HSA-JAK_STAT", "R-HSA-NK_CELL_ACTIVATION", "R-HSA-MUSCLE_HYPERTROPHY"],
    "leptin": ["R-HSA-LEPTIN_SIGNALING", "R-HSA-JAK_STAT", "R-HSA-HYPOTHALAMIC_APPETITE"],
    "adiponectin": ["R-HSA-ADIPOQ_SIGNALING", "R-HSA-AMPK", "R-HSA-INSULIN_SENSITIZATION"],
    "FNDC5": ["R-HSA-UCP1_BROWNING", "R-HSA-PGC1A"],
    "decorin": ["R-HSA-TGF_BETA_SIGNALING", "R-HSA-ECM_ORGANIZATION", "R-HSA-COLLAGEN_FORMATION"],
    "BDNF": ["R-HSA-NEUROTROPHIN_TRKB", "R-HSA-MAPK", "R-HSA-NEURONAL_SURVIVAL"],
    "IL-7": ["R-HSA-JAK_STAT", "R-HSA-LYMPHOCYTE_HOMEOSTASIS"],
    "FSTL1": ["R-HSA-CARDIAC_MUSCLE_PROTECTION", "R-HSA-AMPK", "R-HSA-DIP2_SIGNALING"],
    "apelin": ["R-HSA-APELIN_RECEPTOR", "R-HSA-VASCULAR_HOMEOSTASIS", "R-HSA-AMPK"],
    "CXCL10": ["R-HSA-CHEMOKINE_SIGNALING", "R-HSA-CXCR3", "R-HSA-INTERFERON_GAMMA"],
    "MIF": ["R-HSA-CD74_SIGNALING", "R-HSA-INNATE_IMMUNE", "R-HSA-MAPK"],
    "CTSB": ["R-HSA-LYSOSOMAL_PROTEOLYSIS", "R-HSA-AUTOPHAGY", "R-HSA-NEUROTROPHIN_TRKB"],
    "OSM": ["R-HSA-JAK_STAT", "R-HSA-IL6_FAMILY", "R-HSA-MUSCLE_REGENERATION"]
  }
}