{
  "_comment": "Synthetic / 합성 데모 데이터. 실제 ClinicalTrials.gov/PubMed 레코드가 아님.",
  "schema_note": "index_date = 트라이얼이 색인된 날짜 (YYYY-MM-DD). n_participants = 등록 참가자 수. pico 태그로 SR PICO와 매칭.",
  "trials": [
    {
      "id": "NCT-SYN-101",
      "title_en": "Tirzepatide vs placebo for weight loss in obesity (RCT)",
      "index_date": "2023-06-15",
      "n_participants": 720,
      "study_type": "randomized controlled trial",
      "duration_weeks": 52,
      "pico": {
        "population": ["obesity", "overweight", "adult"],
        "intervention": ["tirzepatide", "glp-1", "drug"],
        "comparator": ["placebo"],
        "outcome": ["body weight", "weight loss", "bmi"]
      }
    },
    {
      "id": "NCT-SYN-102",
      "title_en": "Semaglutide high-dose vs placebo in obesity (RCT)",
      "index_date": "2024-02-20",
      "n_participants": 950,
      "study_type": "randomized controlled trial",
      "duration_weeks": 68,
      "pico": {
        "population": ["obesity", "adult", "BMI>=30"],
        "intervention": ["semaglutide", "glp-1", "drug"],
        "comparator": ["placebo"],
        "outcome": ["body weight", "weight loss"]
      }
    },
    {
      "id": "NCT-SYN-103",
      "title_en": "Liraglutide pediatric obesity trial (RCT) - pre-SR-search",
      "index_date": "2022-03-01",
      "n_participants": 200,
      "study_type": "randomized controlled trial",
      "duration_weeks": 16,
      "pico": {
        "population": ["obesity", "adult", "overweight"],
        "intervention": ["liraglutide", "glp-1", "drug"],
        "comparator": ["placebo"],
        "outcome": ["body weight", "weight loss"]
      }
    },
    {
      "id": "NCT-SYN-201",
      "title_en": "Sleeve gastrectomy vs intensive medical therapy for T2DM remission (RCT)",
      "index_date": "2023-09-10",
      "n_participants": 300,
      "study_type": "randomized controlled trial",
      "duration_weeks": 104,
      "pico": {
        "population": ["obesity", "type 2 diabetes", "t2dm", "adult"],
        "intervention": ["sleeve gastrectomy", "bariatric surgery", "surgery"],
        "comparator": ["medical therapy", "pharmacotherapy"],
        "outcome": ["diabetes remission", "hba1c"]
      }
    },
    {
      "id": "NCT-SYN-301",
      "title_en": "Observational diet cohort (NOT an RCT)",
      "index_date": "2024-05-01",
      "n_participants": 5000,
      "study_type": "observational cohort",
      "duration_weeks": 52,
      "pico": {
        "population": ["overweight", "adult"],
        "intervention": ["diet", "behavioral"],
        "comparator": ["usual care"],
        "outcome": ["body weight"]
      }
    },
    {
      "id": "NCT-SYN-401",
      "title_en": "Cancer immunotherapy trial (off-topic, non-metabolic)",
      "index_date": "2024-04-01",
      "n_participants": 400,
      "study_type": "randomized controlled trial",
      "duration_weeks": 52,
      "pico": {
        "population": ["lung cancer", "adult"],
        "intervention": ["immunotherapy", "pembrolizumab"],
        "comparator": ["chemotherapy"],
        "outcome": ["overall survival"]
      }
    }
  ]
}