======================================================================== PETGlucoFlux — rodent micro-PET 18F-FDG 정량 (오프라인 CLI 시연) ======================================================================== [디스클레이머] 본 도구는 연구용·참고용이며, 정량 결과는 사용자 검증이 필요합니다. 원시 DICOM 재구성은 범위 밖(정량 CSV ingest 전제)이며, 기본 샘플은 합성 데이터입니다. [1] Ingest + decay 보정 (18F t1/2 = 109.77 min, lambda=0.00631 /min) TAC 행수=960 meta 항목=12 input function 곡선=12 모델=C57BL/6 예시: M01/baseline/skeletal_muscle t=36.0 min raw=802.7 -> decay-corr=1007.6 Bq/mL QC 플래그: 없음 [2] SUV 정량 (BW / lean / glucose-corrected) ------------------------------------------------------------------------ animal group timept tissue SUV_bw SUV_lean SUV_glu ------------------------------------------------------------------------ M01 control baseline BAT 0.007 0.005 0.010 M01 control baseline brain 0.012 0.010 0.018 M01 control baseline liver 0.003 0.002 0.004 M01 control baseline myocardium 0.020 0.016 0.029 M01 control baseline skeletal_muscle 0.003 0.003 0.005 M01 control post BAT 0.006 0.005 0.009 M01 control post brain 0.011 0.009 0.017 M01 control post liver 0.003 0.002 0.004 M01 control post myocardium 0.018 0.015 0.028 M01 control post skeletal_muscle 0.003 0.002 0.005 M02 control baseline BAT 0.007 0.005 0.010 M02 control baseline brain 0.012 0.010 0.018 M02 control baseline liver 0.003 0.002 0.004 M02 control baseline myocardium 0.020 0.017 0.030 M02 control baseline skeletal_muscle 0.003 0.003 0.005 M02 control post BAT 0.007 0.005 0.010 M02 control post brain 0.012 0.010 0.018 M02 control post liver 0.003 0.002 0.004 M02 control post myocardium 0.020 0.016 0.030 M02 control post skeletal_muscle 0.003 0.003 0.005 M03 control baseline BAT 0.007 0.006 0.011 M03 control baseline brain 0.013 0.011 0.020 M03 control baseline liver 0.003 0.003 0.005 M03 control baseline myocardium 0.022 0.018 0.032 M03 control baseline skeletal_muscle 0.004 0.003 0.005 M03 control post BAT 0.007 0.005 0.010 M03 control post brain 0.012 0.010 0.018 M03 control post liver 0.003 0.002 0.004 M03 control post myocardium 0.020 0.016 0.030 M03 control post skeletal_muscle 0.003 0.003 0.005 M04 treatment baseline BAT 0.007 0.006 0.011 M04 treatment baseline brain 0.013 0.011 0.021 M04 treatment baseline liver 0.003 0.003 0.005 M04 treatment baseline myocardium 0.022 0.018 0.035 M04 treatment baseline skeletal_muscle 0.004 0.003 0.006 M04 treatment post BAT 0.012 0.009 0.015 M04 treatment post brain 0.012 0.010 0.015 M04 treatment post liver 0.003 0.002 0.004 M04 treatment post myocardium 0.021 0.017 0.028 M04 treatment post skeletal_muscle 0.006 0.005 0.008 M05 treatment baseline BAT 0.007 0.006 0.011 M05 treatment baseline brain 0.013 0.010 0.020 M05 treatment baseline liver 0.003 0.002 0.005 M05 treatment baseline myocardium 0.021 0.017 0.033 M05 treatment baseline skeletal_muscle 0.004 0.003 0.006 M05 treatment post BAT 0.011 0.009 0.014 M05 treatment post brain 0.011 0.009 0.015 M05 treatment post liver 0.003 0.002 0.003 M05 treatment post myocardium 0.020 0.017 0.026 M05 treatment post skeletal_muscle 0.006 0.005 0.008 M06 treatment baseline BAT 0.007 0.006 0.011 M06 treatment baseline brain 0.012 0.010 0.020 M06 treatment baseline liver 0.003 0.002 0.005 M06 treatment baseline myocardium 0.020 0.017 0.033 M06 treatment baseline skeletal_muscle 0.003 0.003 0.005 M06 treatment post BAT 0.012 0.010 0.016 M06 treatment post brain 0.012 0.010 0.016 M06 treatment post liver 0.003 0.002 0.004 M06 treatment post myocardium 0.023 0.018 0.029 M06 treatment post skeletal_muscle 0.007 0.006 0.009 [3] Patlak Ki + MRGlu (LC 보정) ------------------------------------------------------------------------ animal group timept tissue Ki r2 t* LC MRGlu ------------------------------------------------------------------------ M01 control baseline BAT 0.0296 1.000 0.2 1.10 4.033 M01 control baseline brain 0.0544 1.000 0.2 0.60 13.595 M01 control baseline liver 0.0121 1.000 55.0 1.00 1.808 M01 control baseline myocardium 0.0886 1.000 55.0 1.00 13.286 M01 control baseline skeletal_muscle 0.0146 1.000 55.0 1.00 2.186 M01 control post BAT 0.0290 1.000 55.0 1.10 3.948 M01 control post brain 0.0538 1.000 28.0 0.60 13.441 M01 control post liver 0.0120 1.000 0.2 1.00 1.793 M01 control post myocardium 0.0895 1.000 0.2 1.00 13.420 M01 control post skeletal_muscle 0.0148 1.000 0.2 1.00 2.222 M02 control baseline BAT 0.0294 1.000 28.0 1.10 4.008 M02 control baseline brain 0.0533 1.000 55.0 0.60 13.323 M02 control baseline liver 0.0121 1.000 55.0 1.00 1.813 M02 control baseline myocardium 0.0869 1.000 55.0 1.00 13.030 M02 control baseline skeletal_muscle 0.0148 1.000 0.2 1.00 2.215 M02 control post BAT 0.0305 1.000 55.0 1.10 4.166 M02 control post brain 0.0556 1.000 36.0 0.60 13.895 M02 control post liver 0.0117 1.000 55.0 1.00 1.748 M02 control post myocardium 0.0886 1.000 0.2 1.00 13.284 M02 control post skeletal_muscle 0.0152 1.000 55.0 1.00 2.282 M03 control baseline BAT 0.0304 1.000 55.0 1.10 4.139 M03 control baseline brain 0.0540 1.000 0.2 0.60 13.496 M03 control baseline liver 0.0120 1.000 0.2 1.00 1.804 M03 control baseline myocardium 0.0893 1.000 0.2 1.00 13.398 M03 control baseline skeletal_muscle 0.0146 1.000 55.0 1.00 2.185 M03 control post BAT 0.0293 1.000 45.0 1.10 4.002 M03 control post brain 0.0558 1.000 55.0 0.60 13.962 M03 control post liver 0.0117 1.000 55.0 1.00 1.755 M03 control post myocardium 0.0907 1.000 0.2 1.00 13.607 M03 control post skeletal_muscle 0.0146 1.000 0.2 1.00 2.194 M04 treatment baseline BAT 0.0294 1.000 0.2 1.10 4.275 M04 treatment baseline brain 0.0545 1.000 55.0 0.60 14.529 M04 treatment baseline liver 0.0118 1.000 55.0 1.00 1.884 M04 treatment baseline myocardium 0.0905 1.000 55.0 1.00 14.484 M04 treatment baseline skeletal_muscle 0.0148 1.000 0.2 1.00 2.373 M04 treatment post BAT 0.0532 1.000 0.2 1.10 6.284 M04 treatment post brain 0.0539 1.000 45.0 0.60 11.678 M04 treatment post liver 0.0116 1.000 55.0 1.00 1.509 M04 treatment post myocardium 0.0994 1.000 45.0 1.00 12.916 M04 treatment post skeletal_muscle 0.0300 1.000 55.0 1.00 3.894 M05 treatment baseline BAT 0.0298 1.000 16.0 1.10 4.328 M05 treatment baseline brain 0.0533 1.000 45.0 0.60 14.200 M05 treatment baseline liver 0.0120 1.000 55.0 1.00 1.913 M05 treatment baseline myocardium 0.0874 1.000 45.0 1.00 13.980 M05 treatment baseline skeletal_muscle 0.0148 1.000 0.2 1.00 2.361 M05 treatment post BAT 0.0521 1.000 55.0 1.10 6.160 M05 treatment post brain 0.0550 1.000 0.2 0.60 11.924 M05 treatment post liver 0.0118 1.000 55.0 1.00 1.528 M05 treatment post myocardium 0.0973 1.000 0.2 1.00 12.650 M05 treatment post skeletal_muscle 0.0296 1.000 55.0 1.00 3.848 M06 treatment baseline BAT 0.0298 1.000 0.2 1.10 4.337 M06 treatment baseline brain 0.0548 1.000 0.2 0.60 14.626 M06 treatment baseline liver 0.0118 1.000 55.0 1.00 1.889 M06 treatment baseline myocardium 0.0906 1.000 55.0 1.00 14.494 M06 treatment baseline skeletal_muscle 0.0148 1.000 0.2 1.00 2.374 M06 treatment post BAT 0.0524 1.000 55.0 1.10 6.193 M06 treatment post brain 0.0551 1.000 0.2 0.60 11.928 M06 treatment post liver 0.0116 1.000 55.0 1.00 1.502 M06 treatment post myocardium 0.0996 1.000 0.2 1.00 12.951 M06 treatment post skeletal_muscle 0.0300 1.000 55.0 1.00 3.906 [4] 종단 within-animal 변화 (paired baseline -> post) ------------------------------------------------------------------------ animal group tissue baseline post delta pct% (metric: Ki) ------------------------------------------------------------------------ M01 control BAT 0.0296 0.0290 -0.0006 -2.1% M01 control brain 0.0544 0.0538 -0.0006 -1.1% M01 control liver 0.0121 0.0120 -0.0001 -0.8% M01 control myocardium 0.0886 0.0895 0.0009 1.0% M01 control skeletal_muscle 0.0146 0.0148 0.0002 1.6% M02 control BAT 0.0294 0.0305 0.0012 3.9% M02 control brain 0.0533 0.0556 0.0023 4.3% M02 control liver 0.0121 0.0117 -0.0004 -3.6% M02 control myocardium 0.0869 0.0886 0.0017 2.0% M02 control skeletal_muscle 0.0148 0.0152 0.0004 3.0% M03 control BAT 0.0304 0.0293 -0.0010 -3.3% M03 control brain 0.0540 0.0558 0.0019 3.4% M03 control liver 0.0120 0.0117 -0.0003 -2.7% M03 control myocardium 0.0893 0.0907 0.0014 1.6% M03 control skeletal_muscle 0.0146 0.0146 0.0001 0.4% M04 treatment BAT 0.0294 0.0532 0.0238 80.9% M04 treatment brain 0.0545 0.0539 -0.0006 -1.1% M04 treatment liver 0.0118 0.0116 -0.0002 -1.4% M04 treatment myocardium 0.0905 0.0994 0.0088 9.8% M04 treatment skeletal_muscle 0.0148 0.0300 0.0151 102.0% M05 treatment BAT 0.0298 0.0521 0.0224 75.2% M05 treatment brain 0.0533 0.0550 0.0018 3.4% M05 treatment liver 0.0120 0.0118 -0.0002 -1.6% M05 treatment myocardium 0.0874 0.0973 0.0099 11.4% M05 treatment skeletal_muscle 0.0148 0.0296 0.0148 100.6% M06 treatment BAT 0.0298 0.0524 0.0226 75.7% M06 treatment brain 0.0548 0.0551 0.0002 0.4% M06 treatment liver 0.0118 0.0116 -0.0003 -2.1% M06 treatment myocardium 0.0906 0.0996 0.0090 10.0% M06 treatment skeletal_muscle 0.0148 0.0300 0.0152 102.5% [4b] 모델 참고 범위 / 메타데이터 경고 (model=C57BL/6) - 참고범위 이탈 [C57BL/6] M01/baseline BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M01/baseline brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M01/baseline liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M01/baseline myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M01/baseline skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M01/post BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M01/post brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M01/post liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M01/post myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M01/post skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M02/baseline BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M02/baseline brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M02/baseline liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M02/baseline myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M02/baseline skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M02/post BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M02/post brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M02/post liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M02/post myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M02/post skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M03/baseline BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M03/baseline brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M03/baseline liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M03/baseline myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M03/baseline skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M03/post BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M03/post brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M03/post liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M03/post myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M03/post skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M04/baseline BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M04/baseline brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M04/baseline liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M04/baseline myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M04/baseline skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M04/post BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M04/post brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M04/post liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M04/post myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M04/post skeletal_muscle: SUV_bw=0.01 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M05/baseline BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M05/baseline brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M05/baseline liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M05/baseline myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M05/baseline skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M05/post BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M05/post brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M05/post liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M05/post myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M05/post skeletal_muscle: SUV_bw=0.01 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M06/baseline BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M06/baseline brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M06/baseline liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M06/baseline myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M06/baseline skeletal_muscle: SUV_bw=0.00 (C57BL/6 참고 0.30-1.50) - 참고범위 이탈 [C57BL/6] M06/post BAT: SUV_bw=0.01 (C57BL/6 참고 1.00-8.00) - 참고범위 이탈 [C57BL/6] M06/post brain: SUV_bw=0.01 (C57BL/6 참고 1.00-3.50) - 참고범위 이탈 [C57BL/6] M06/post liver: SUV_bw=0.00 (C57BL/6 참고 0.30-1.20) - 참고범위 이탈 [C57BL/6] M06/post myocardium: SUV_bw=0.02 (C57BL/6 참고 3.00-10.00) - 참고범위 이탈 [C57BL/6] M06/post skeletal_muscle: SUV_bw=0.01 (C57BL/6 참고 0.30-1.50) 메타데이터 누락 경고 없음 [5] Cohort 통계 (Ki paired t-test: baseline vs post) ------------------------------------------------------------------------ group tissue n mean_dKi p(paired) ------------------------------------------------------------------------ control BAT 3 -0.0002 0.8352 control brain 3 0.0012 0.3234 control liver 3 -0.0003 0.1044 control myocardium 3 0.0013 0.0294 control skeletal_muscle 3 0.0002 0.1540 treatment BAT 3 0.0229 0.0004 treatment brain 3 0.0005 0.5712 treatment liver 3 -0.0002 0.0139 treatment myocardium 3 0.0093 0.0013 treatment skeletal_muscle 3 0.0151 0.0001 [5b] Mechanism 분류 (treatment 군 종단 Ki 변화 기반) => 근육 흡수 개선형 (skeletal muscle uptake) 근육 흡수 개선형 (skeletal muscle uptake) 평균 pct_change = 101.7 BAT 활성형 (brown adipose activation) 평균 pct_change = 77.3 심근 변화형 (myocardial shift) 평균 pct_change = 10.4 [6] 요약 리포트 (국문/영문) ======================================================================== [국문] 6마리·5조직 micro-PET 18F-FDG TAC 를 18F decay 보정 후 SUV(BW/lean/glucose) 와 Patlak Ki·LC 보정 MRGlu 로 정량하였다. treatment 군 골격근 Ki 의 종단 변화량은 평균 0.0151 (paired p=0.0001) 였다. 본 cohort 의 주된 기전은 '근육 흡수 개선형 (skeletal muscle uptake)' 로 분류되었다 (모델 참고: C57BL/6). [EN] Rodent micro-PET 18F-FDG TACs from 6 animals across 5 tissues were decay-corrected (18F) and quantified as SUV (BW/lean/glucose) and Patlak Ki with lumped-constant-corrected MRGlu. The longitudinal change in skeletal muscle Ki for the treatment group was 0.0151 on average (paired p=0.0001). The dominant mechanism of this cohort was classified as '근육 흡수 개선형 (skeletal muscle uptake)' (reference model: C57BL/6). [디스클레이머] 본 도구는 연구용·참고용이며, 정량 결과는 사용자 검증이 필요합니다. 원시 DICOM 재구성은 범위 밖(정량 CSV ingest 전제)이며, 기본 샘플은 합성 데이터입니다.