{
  "label_rules": [
    {"label": "incretin", "keywords": ["GLP-1", "glp1", "GIP", "incretin", "semaglutide", "tirzepatide", "retatrutide", "dulaglutide", "liraglutide", "exenatide"]},
    {"label": "MC4R_pathway", "keywords": ["MC4R", "melanocortin", "POMC", "setmelanotide", "AgRP", "leptin-melanocortin"]},
    {"label": "leptin_axis", "keywords": ["leptin", "leptin receptor", "LEPR", "metreleptin", "hypothalamic"]},
    {"label": "GDF15", "keywords": ["GDF15", "GDF-15", "GFRAL", "growth differentiation factor 15", "MIC-1"]},
    {"label": "orexin", "keywords": ["orexin", "hypocretin", "OX2R", "OX1R"]},
    {"label": "brown_fat", "keywords": ["brown fat", "BAT", "thermogenesis", "UCP1", "beige adipocyte", "browning", "cold exposure"]},
    {"label": "sarcopenic_obesity", "keywords": ["sarcopenic obesity", "sarcopenia", "muscle wasting", "myosteatosis", "lean mass", "appendicular"]},
    {"label": "gut_microbiome_obesity", "keywords": ["microbiome", "microbiota", "Akkermansia", "Bacteroides", "Firmicutes", "SCFA", "short-chain fatty acid", "gut-brain"]},
    {"label": "bariatric", "keywords": ["bariatric", "RYGB", "sleeve gastrectomy", "metabolic surgery", "Roux-en-Y", "duodenal switch"]},
    {"label": "obesity_genetics", "keywords": ["FTO", "MC4R variant", "PCSK1", "monogenic obesity", "polygenic", "GWAS obesity"]},
    {"label": "adipose_inflammation", "keywords": ["adipose tissue macrophage", "ATM", "adipose inflammation", "M1 M2", "CLS", "crown-like structure"]},
    {"label": "energy_expenditure", "keywords": ["energy expenditure", "indirect calorimetry", "REE", "BMR", "metabolic rate"]},
    {"label": "pediatric_obesity", "keywords": ["pediatric obesity", "childhood obesity", "adolescent BMI"]}
  ]
}