{
  "preprints": [
    {
      "id": "BX-2026-0501",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.01.000001",
      "title": "GFRAL agonism in diet-induced obese mice synergizes with semaglutide to suppress feeding without aversion",
      "authors": ["J. Mueller", "T. Brand", "H. Eberhardt"],
      "affiliations": ["Heidelberg Adiposity Center", "Heidelberg University Hospital"],
      "abstract": "We tested a GDF15-mimetic peptide combined with semaglutide in DIO C57BL/6J mice. Combination reduced food intake 38% vs semaglutide alone without conditioned taste aversion. GFRAL knockout abolished the effect. Indirect calorimetry showed preserved energy expenditure.",
      "posted_date": "2026-05-01",
      "version": 1,
      "subject": "Physiology",
      "data_links": ["https://github.com/heidelberg-adipose/gdf15-sema-2026", "https://zenodo.org/record/9000001"],
      "code_links": ["https://github.com/heidelberg-adipose/gdf15-sema-2026"],
      "protocol_links": ["https://protocols.io/view/gdf15-sema-dio-2026"]
    },
    {
      "id": "BX-2026-0502",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.02.000002",
      "title": "Single-nucleus transcriptomics of human supraclavicular brown adipose tissue across a BMI spectrum",
      "authors": ["F. Ouellet", "P. Beaulieu", "M. Roy"],
      "affiliations": ["Montreal Brown Adipose Lab", "Universite de Montreal"],
      "abstract": "snRNA-seq of 32 supraclavicular BAT biopsies (BMI 19-42). UCP1+ adipocyte fraction declined linearly with BMI. A novel beige progenitor cluster expressing CITED1 and TMEM26 was enriched in lean donors.",
      "posted_date": "2026-05-02",
      "version": 1,
      "subject": "Cell Biology",
      "data_links": ["https://github.com/montreal-bat/snrna-bat-2026", "https://zenodo.org/record/9000002"],
      "code_links": ["https://github.com/montreal-bat/snrna-bat-2026"],
      "protocol_links": ["https://protocols.io/view/bat-snrna-2026"]
    },
    {
      "id": "MX-2026-0503",
      "server": "medRxiv",
      "doi": "10.1101/2026.05.03.000003",
      "title": "Tirzepatide 15 mg vs semaglutide 2.4 mg in adults with obesity and type 2 diabetes: 72-week randomized trial",
      "authors": ["R. Devarajan", "S. Iyer", "P. Krishnan"],
      "affiliations": ["Chennai Diabetes Research Foundation"],
      "abstract": "Multicenter open-label RCT, n=812. Mean weight loss 22.1% vs 15.4% (p<0.001). HbA1c reduction 2.3% vs 1.8%. GI adverse events similar. Sarcopenia indices favored tirzepatide.",
      "posted_date": "2026-05-03",
      "version": 1,
      "subject": "Endocrinology",
      "data_links": [],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/tzp-sema-rct-2026"]
    },
    {
      "id": "RS-2026-0504",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0504",
      "title": "Gut Akkermansia muciniphila abundance predicts GLP-1 receptor agonist response in a Korean cohort",
      "authors": ["Y. Han", "J. Park", "S. Kim"],
      "affiliations": ["Seoul Metabolic Network"],
      "abstract": "Prospective cohort of 240 adults initiating semaglutide. Baseline A. muciniphila >2% predicted >10% weight loss at 24 weeks (OR 3.1, 95% CI 1.8-5.4). Validated in independent n=180.",
      "posted_date": "2026-05-04",
      "version": 1,
      "subject": "Microbiology",
      "data_links": ["https://osf.io/akk-glp1-2026"],
      "code_links": [],
      "protocol_links": []
    },
    {
      "id": "CX-2026-0505",
      "server": "ChemRxiv",
      "doi": "10.26434/chemrxiv-2026-0505",
      "title": "Structure-guided design of orally bioavailable MC4R agonists with reduced cardiovascular off-target liability",
      "authors": ["M. Lindqvist", "E. Bergstrom", "A. Holm"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "We report a series of cyclic peptide MC4R agonists with >300-fold selectivity over MC1R/MC3R and minimal hERG inhibition. Lead compound KL-441 achieved 18% weight loss in DIO rats over 28 days.",
      "posted_date": "2026-05-05",
      "version": 1,
      "subject": "Medicinal Chemistry",
      "data_links": ["https://github.com/karolinska-obesity/mc4r-2026"],
      "code_links": ["https://github.com/karolinska-obesity/mc4r-2026"],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0506",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.06.000006",
      "title": "Hypothalamic orexin neurons mediate the anti-obesity effect of intermittent cold exposure",
      "authors": ["F. Ouellet", "C. Lemieux"],
      "affiliations": ["Montreal Brown Adipose Lab"],
      "abstract": "Chemogenetic silencing of LH orexin neurons abolished cold-induced UCP1 upregulation in BAT and energy expenditure increases. Orexin-A infusion phenocopied cold exposure.",
      "posted_date": "2026-05-06",
      "version": 2,
      "subject": "Neuroscience",
      "data_links": ["https://github.com/montreal-bat/orexin-cold-2026"],
      "code_links": ["https://github.com/montreal-bat/orexin-cold-2026"],
      "protocol_links": ["https://protocols.io/view/orexin-cold-2026"]
    },
    {
      "id": "MX-2026-0507",
      "server": "medRxiv",
      "doi": "10.1101/2026.05.07.000007",
      "title": "Sarcopenic obesity prevalence in Korean adults >=65: KNHANES 2018-2024 analysis",
      "authors": ["Y. Han", "M. Lee"],
      "affiliations": ["Seoul Metabolic Network"],
      "abstract": "Cross-sectional analysis of 12,400 adults. Sarcopenic obesity prevalence 14.2% (men) and 18.9% (women) by AWGS 2019 criteria. Associated with 2.4-fold higher incident frailty.",
      "posted_date": "2026-05-07",
      "version": 1,
      "subject": "Geriatrics",
      "data_links": [],
      "code_links": [],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0508",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.08.000008",
      "title": "Adipose tissue macrophage CLS density tracks insulin resistance independent of BMI in MASLD",
      "authors": ["L. Costa", "R. Almeida", "P. Santos"],
      "affiliations": ["Sao Paulo Adipose Biology Lab"],
      "abstract": "Visceral adipose biopsies from 86 MASLD patients. Crown-like structure (CLS) density correlated with HOMA-IR (r=0.61) after adjustment for BMI and waist circumference.",
      "posted_date": "2026-05-08",
      "version": 1,
      "subject": "Pathology",
      "data_links": ["https://zenodo.org/record/9000008"],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/cls-quant-2026"]
    },
    {
      "id": "RS-2026-0509",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0509",
      "title": "Polygenic risk score for adult BMI in West African ancestry: trans-ethnic GWAS meta-analysis",
      "authors": ["S. Okafor", "B. Adeyemi"],
      "affiliations": ["Lagos Endocrine Research Unit"],
      "abstract": "GWAS meta-analysis (n=58,000 West African ancestry). PRS explained 6.8% BMI variance vs 3.1% with European-derived PRS. Two novel loci near LEPR and PCSK1.",
      "posted_date": "2026-05-09",
      "version": 1,
      "subject": "Genetics",
      "data_links": ["https://zenodo.org/record/9000009", "https://osf.io/west-african-bmi-prs"],
      "code_links": ["https://github.com/lagos-endo/wa-bmi-prs"],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0510",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.10.000010",
      "title": "GDF15-GFRAL signaling mediates metformin-induced anorexia in lean and obese mice",
      "authors": ["J. Mueller", "K. Wagner"],
      "affiliations": ["Heidelberg Adiposity Center"],
      "abstract": "Metformin elevated circulating GDF15 dose-dependently. GFRAL-/- mice lacked metformin-induced food intake suppression. Effect preserved in DIO and lean groups.",
      "posted_date": "2026-05-10",
      "version": 1,
      "subject": "Pharmacology",
      "data_links": ["https://github.com/heidelberg-adipose/met-gdf15-2026"],
      "code_links": ["https://github.com/heidelberg-adipose/met-gdf15-2026"],
      "protocol_links": []
    },
    {
      "id": "MX-2026-0511",
      "server": "medRxiv",
      "doi": "10.1101/2026.05.11.000011",
      "title": "Retatrutide 12 mg vs placebo in MASH with obesity: 48-week phase 2 trial",
      "authors": ["R. Devarajan", "K. Vasudevan"],
      "affiliations": ["Chennai Diabetes Research Foundation"],
      "abstract": "Phase 2 RCT, n=240. MASH resolution 51% vs 12% (p<0.001). Fibrosis improvement >=1 stage 38% vs 18%. Weight loss 21.4% vs 1.2%.",
      "posted_date": "2026-05-11",
      "version": 1,
      "subject": "Hepatology",
      "data_links": [],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/reta-mash-2026"]
    },
    {
      "id": "BX-2026-0512",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.12.000012",
      "title": "POMC neuron-specific deletion of LEPR causes adult-onset hyperphagic obesity without diabetes",
      "authors": ["M. Lindqvist", "T. Ekman"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "Conditional LEPR knockout in POMC neurons induced 42% weight gain by 24 weeks without impaired glucose tolerance. Energy expenditure was preserved.",
      "posted_date": "2026-05-12",
      "version": 1,
      "subject": "Neuroscience",
      "data_links": ["https://github.com/karolinska-obesity/pomc-lepr-2026"],
      "code_links": ["https://github.com/karolinska-obesity/pomc-lepr-2026"],
      "protocol_links": ["https://protocols.io/view/pomc-lepr-cko-2026"]
    },
    {
      "id": "RS-2026-0513",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0513",
      "title": "Sleeve gastrectomy outcomes in adolescents with Prader-Willi syndrome: 5-year follow-up",
      "authors": ["A. Petrov", "N. Volkov"],
      "affiliations": ["Moscow Bariatric Clinic"],
      "abstract": "Case series n=18 adolescents with PWS undergoing sleeve gastrectomy. Mean BMI reduction 11.2 kg/m2 at 1 year, attenuated to 5.8 at 5 years. Behavioral hyperphagia returned in 14/18.",
      "posted_date": "2026-05-13",
      "version": 1,
      "subject": "Surgery",
      "data_links": [],
      "code_links": [],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0514",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.14.000014",
      "title": "Beige adipocyte recruitment via CL316,243 fails in aged mice due to senescent ASC accumulation",
      "authors": ["F. Ouellet", "M. Roy"],
      "affiliations": ["Montreal Brown Adipose Lab"],
      "abstract": "Aged C57BL/6 mice showed blunted UCP1 induction after CL316,243. Senolytic dasatinib+quercetin restored beige recruitment by clearing p16+ adipose stem cells.",
      "posted_date": "2026-05-14",
      "version": 1,
      "subject": "Aging",
      "data_links": ["https://github.com/montreal-bat/beige-senescence-2026"],
      "code_links": ["https://github.com/montreal-bat/beige-senescence-2026"],
      "protocol_links": ["https://protocols.io/view/beige-senolytic-2026"]
    },
    {
      "id": "CX-2026-0515",
      "server": "ChemRxiv",
      "doi": "10.26434/chemrxiv-2026-0515",
      "title": "Oral nonpeptide GLP-1/GIP/glucagon triagonist with mucosal permeability enhancer",
      "authors": ["M. Lindqvist", "G. Persson"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "Small-molecule triagonist KL-509 achieved 14% weight loss in DIO mice via oral dosing. SNAC permeability enhancer improved bioavailability 8-fold.",
      "posted_date": "2026-05-15",
      "version": 1,
      "subject": "Medicinal Chemistry",
      "data_links": ["https://github.com/karolinska-obesity/triagonist-2026"],
      "code_links": ["https://github.com/karolinska-obesity/triagonist-2026"],
      "protocol_links": []
    },
    {
      "id": "MX-2026-0516",
      "server": "medRxiv",
      "doi": "10.1101/2026.05.16.000016",
      "title": "Lean mass preservation with resistance training during tirzepatide treatment: randomized adjunct trial",
      "authors": ["S. Okafor", "C. Adesina"],
      "affiliations": ["Lagos Endocrine Research Unit"],
      "abstract": "RCT n=160 adults on tirzepatide randomized to supervised resistance training vs usual care over 36 weeks. ALM/height2 declined 6.1% vs 12.3% (p<0.001). Total weight loss similar.",
      "posted_date": "2026-05-16",
      "version": 1,
      "subject": "Sports Medicine",
      "data_links": ["https://osf.io/tzp-resistance-2026"],
      "code_links": ["https://github.com/lagos-endo/tzp-rt-2026"],
      "protocol_links": ["https://protocols.io/view/tzp-rt-rct-2026"]
    },
    {
      "id": "BX-2026-0517",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.17.000017",
      "title": "Intestinal Bacteroides thetaiotaomicron-derived SCFAs activate FFAR3 on enteroendocrine L cells to potentiate GLP-1 release",
      "authors": ["H. Tanaka", "K. Ito"],
      "affiliations": ["Kyoto Metabolic Institute"],
      "abstract": "Gnotobiotic mice colonized with B. thetaiotaomicron showed 2.3-fold higher post-prandial GLP-1. FFAR3 knockout abolished the effect.",
      "posted_date": "2026-05-17",
      "version": 1,
      "subject": "Microbiology",
      "data_links": ["https://github.com/kyoto-metab/bt-glp1-2026", "https://zenodo.org/record/9000017"],
      "code_links": ["https://github.com/kyoto-metab/bt-glp1-2026"],
      "protocol_links": ["https://protocols.io/view/bt-glp1-2026"]
    },
    {
      "id": "RS-2026-0518",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0518",
      "title": "Childhood BMI trajectories and incident type 2 diabetes by age 25: Portuguese birth cohort",
      "authors": ["K. Almeida", "P. Ferreira"],
      "affiliations": ["Lisbon Pediatric Obesity Cohort"],
      "abstract": "Birth cohort n=2,400 followed 0-25 years. Latent class trajectory analysis identified 'early-rising obesity' group (8.2%) with 6.1-fold increased T2D risk.",
      "posted_date": "2026-05-18",
      "version": 1,
      "subject": "Epidemiology",
      "data_links": [],
      "code_links": ["https://github.com/lisbon-peds/bmi-traj-2026"],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0519",
      "server": "bioRxiv",
      "doi": "10.1101/2026.05.19.000019",
      "title": "MC4R variant p.Tyr35Ter: complete loss of function rescued by setmelanotide in human iPSC-derived hypothalamic neurons",
      "authors": ["M. Lindqvist", "S. Johansson"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "iPSC lines from a patient with MC4R p.Tyr35Ter differentiated into hypothalamic neurons. Setmelanotide restored cAMP signaling to 78% of WT.",
      "posted_date": "2026-05-19",
      "version": 1,
      "subject": "Cell Biology",
      "data_links": ["https://github.com/karolinska-obesity/mc4r-ipsc-2026", "https://zenodo.org/record/9000019"],
      "code_links": ["https://github.com/karolinska-obesity/mc4r-ipsc-2026"],
      "protocol_links": ["https://protocols.io/view/mc4r-ipsc-2026"]
    },
    {
      "id": "MX-2026-0520",
      "server": "medRxiv",
      "doi": "10.1101/2026.05.20.000020",
      "title": "GLP-1 RA discontinuation rebound: 12-month real-world cohort from a multi-clinic network",
      "authors": ["Y. Han", "J. Choi"],
      "affiliations": ["Seoul Metabolic Network"],
      "abstract": "n=1,820 GLP-1 RA discontinuers. Mean regain 68% of lost weight by 12 months. Lifestyle intensity at discontinuation modified rebound trajectory.",
      "posted_date": "2026-05-20",
      "version": 1,
      "subject": "Endocrinology",
      "data_links": [],
      "code_links": [],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0420",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.20.000420",
      "title": "Adipose ATM polarization in human obesity: spatial transcriptomics across visceral and subcutaneous depots",
      "authors": ["L. Costa", "M. Pereira"],
      "affiliations": ["Sao Paulo Adipose Biology Lab"],
      "abstract": "Visium spatial transcriptomics on paired VAT/SAT biopsies from 24 obese adults. M1-like CLS were 4-fold enriched in VAT; M2-like populations dominated SAT.",
      "posted_date": "2026-04-20",
      "version": 2,
      "subject": "Genomics",
      "data_links": ["https://github.com/sp-adipose/spatial-atm-2026", "https://zenodo.org/record/9000420"],
      "code_links": ["https://github.com/sp-adipose/spatial-atm-2026"],
      "protocol_links": ["https://protocols.io/view/visium-atm-2026"]
    },
    {
      "id": "BX-2026-0422",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.22.000422",
      "title": "UCP1-independent thermogenesis via creatine futile cycling in beige adipocytes",
      "authors": ["F. Ouellet", "P. Beaulieu"],
      "affiliations": ["Montreal Brown Adipose Lab"],
      "abstract": "GATM/GAMT knockout beige adipocytes lost cold-induced thermogenesis despite intact UCP1. Creatine supplementation rescued thermogenic capacity.",
      "posted_date": "2026-04-22",
      "version": 1,
      "subject": "Biochemistry",
      "data_links": ["https://github.com/montreal-bat/creatine-cycle-2026"],
      "code_links": ["https://github.com/montreal-bat/creatine-cycle-2026"],
      "protocol_links": []
    },
    {
      "id": "MX-2026-0424",
      "server": "medRxiv",
      "doi": "10.1101/2026.04.24.000424",
      "title": "Indirect calorimetry-measured REE underestimates predicted equations in adults with class III obesity",
      "authors": ["S. Okafor", "F. Adebayo"],
      "affiliations": ["Lagos Endocrine Research Unit"],
      "abstract": "Comparative study n=320 class III obesity adults. Mifflin-St Jeor overestimated REE by 280 kcal/day vs measured. Harris-Benedict overestimated by 410 kcal/day.",
      "posted_date": "2026-04-24",
      "version": 1,
      "subject": "Nutrition",
      "data_links": ["https://osf.io/ree-class3-2026"],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/ree-class3-2026"]
    },
    {
      "id": "RS-2026-0425",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0425",
      "title": "Bariatric surgery and bone mineral density loss: 10-year prospective registry",
      "authors": ["A. Petrov", "I. Sokolov"],
      "affiliations": ["Moscow Bariatric Clinic"],
      "abstract": "Registry n=2,800 RYGB and SG patients. Mean femoral neck BMD T-score declined 0.9 SD at 10 years post-RYGB vs 0.4 SD post-SG. Fracture risk increased 1.8-fold.",
      "posted_date": "2026-04-25",
      "version": 2,
      "subject": "Orthopedics",
      "data_links": [],
      "code_links": [],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0427",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.27.000427",
      "title": "Hypothalamic FTO variant rs9939609 alters food cue reactivity in human iPSC neurons",
      "authors": ["M. Lindqvist", "L. Andersson"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "Isogenic iPSC lines differing only at rs9939609 differentiated into hypothalamic neurons. Risk allele increased m6A methylation of feeding-related transcripts including ANK1 and AGRP.",
      "posted_date": "2026-04-27",
      "version": 1,
      "subject": "Genetics",
      "data_links": ["https://github.com/karolinska-obesity/fto-ipsc-2026"],
      "code_links": ["https://github.com/karolinska-obesity/fto-ipsc-2026"],
      "protocol_links": ["https://protocols.io/view/fto-ipsc-2026"]
    },
    {
      "id": "CX-2026-0428",
      "server": "ChemRxiv",
      "doi": "10.26434/chemrxiv-2026-0428",
      "title": "PROTAC-mediated GIPR degradation as obesity therapy: proof of concept",
      "authors": ["H. Tanaka", "S. Nakamura"],
      "affiliations": ["Kyoto Metabolic Institute"],
      "abstract": "GIPR-targeting PROTAC HT-77 degraded receptor 80% in adipocytes. DIO mice treated showed 16% weight loss over 21 days. Mechanism distinct from GIPR antagonism.",
      "posted_date": "2026-04-28",
      "version": 1,
      "subject": "Chemical Biology",
      "data_links": ["https://github.com/kyoto-metab/protac-gipr-2026"],
      "code_links": ["https://github.com/kyoto-metab/protac-gipr-2026"],
      "protocol_links": []
    },
    {
      "id": "MX-2026-0429",
      "server": "medRxiv",
      "doi": "10.1101/2026.04.29.000429",
      "title": "Semaglutide use and incident gallbladder disease: target trial emulation in US claims",
      "authors": ["R. Devarajan", "M. Iyengar"],
      "affiliations": ["Chennai Diabetes Research Foundation"],
      "abstract": "Target trial emulation in 380,000 new semaglutide users vs matched non-users. HR for incident cholecystitis 1.42 (95% CI 1.28-1.58) over 24 months.",
      "posted_date": "2026-04-29",
      "version": 1,
      "subject": "Pharmacoepidemiology",
      "data_links": [],
      "code_links": ["https://github.com/chennai-drf/sema-gb-2026"],
      "protocol_links": ["https://protocols.io/view/sema-gb-tte-2026"]
    },
    {
      "id": "BX-2026-0430",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.30.000430",
      "title": "AgRP neuron activation drives compensatory hyperphagia after GLP-1 RA withdrawal",
      "authors": ["H. Tanaka", "Y. Sato"],
      "affiliations": ["Kyoto Metabolic Institute"],
      "abstract": "Fiber photometry of AgRP neurons during semaglutide treatment and withdrawal. Post-withdrawal AgRP activity exceeded baseline by 35% for 14 days, correlating with rebound feeding.",
      "posted_date": "2026-04-30",
      "version": 1,
      "subject": "Neuroscience",
      "data_links": ["https://github.com/kyoto-metab/agrp-withdraw-2026", "https://zenodo.org/record/9000430"],
      "code_links": ["https://github.com/kyoto-metab/agrp-withdraw-2026"],
      "protocol_links": ["https://protocols.io/view/agrp-photometry-2026"]
    },
    {
      "id": "RS-2026-0501",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.05010",
      "title": "Pediatric obesity remission with intensive lifestyle plus liraglutide: pragmatic Lisbon cohort",
      "authors": ["K. Almeida", "J. Sousa"],
      "affiliations": ["Lisbon Pediatric Obesity Cohort"],
      "abstract": "Pragmatic cohort n=180 children 12-17 with class II obesity. Combined liraglutide + lifestyle achieved 25% BMI z-score reduction at 12 months vs 8% with lifestyle alone.",
      "posted_date": "2026-05-01",
      "version": 1,
      "subject": "Pediatrics",
      "data_links": [],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/peds-liraglutide-2026"]
    },
    {
      "id": "BX-2026-0405",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.05.000405",
      "title": "Hepatocyte-specific PNPLA3 I148M overexpression accelerates MASLD in DIO mice",
      "authors": ["L. Costa", "T. Lima"],
      "affiliations": ["Sao Paulo Adipose Biology Lab"],
      "abstract": "AAV8-mediated hepatocyte PNPLA3 I148M induced steatosis and fibrosis within 16 weeks of HFD. Effect was independent of weight gain.",
      "posted_date": "2026-04-05",
      "version": 1,
      "subject": "Hepatology",
      "data_links": ["https://github.com/sp-adipose/pnpla3-2026"],
      "code_links": ["https://github.com/sp-adipose/pnpla3-2026"],
      "protocol_links": []
    },
    {
      "id": "MX-2026-0407",
      "server": "medRxiv",
      "doi": "10.1101/2026.04.07.000407",
      "title": "Setmelanotide in monogenic obesity outside MC4R pathway: case series of LEPR and POMC patients",
      "authors": ["M. Lindqvist", "S. Holmberg"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "Case series n=24 patients with LEPR or POMC deficiency. Mean BMI reduction 18.4% at 12 months. Hyperphagia score improved in 92%.",
      "posted_date": "2026-04-07",
      "version": 1,
      "subject": "Endocrinology",
      "data_links": [],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/set-monogenic-2026"]
    },
    {
      "id": "BX-2026-0409",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.09.000409",
      "title": "Intermittent fasting selectively depletes visceral adipose tissue via SNS-mediated lipolysis",
      "authors": ["H. Tanaka", "M. Kobayashi"],
      "affiliations": ["Kyoto Metabolic Institute"],
      "abstract": "16:8 IF in DIO mice reduced VAT 28% vs 12% SAT loss. Sympathetic denervation of VAT abolished depot specificity.",
      "posted_date": "2026-04-09",
      "version": 1,
      "subject": "Physiology",
      "data_links": ["https://github.com/kyoto-metab/if-vat-2026"],
      "code_links": ["https://github.com/kyoto-metab/if-vat-2026"],
      "protocol_links": ["https://protocols.io/view/if-vat-2026"]
    },
    {
      "id": "RS-2026-0411",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0411",
      "title": "Body composition changes during weight regain after GLP-1 RA discontinuation: DXA cohort",
      "authors": ["S. Okafor", "T. Ogundele"],
      "affiliations": ["Lagos Endocrine Research Unit"],
      "abstract": "DXA before/during/after semaglutide in 220 adults. Regain phase was 72% fat mass, 28% lean mass on average. Sarcopenic obesity incidence rose 14% post-discontinuation.",
      "posted_date": "2026-04-11",
      "version": 1,
      "subject": "Body Composition",
      "data_links": ["https://osf.io/dxa-glp1-discont-2026"],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/dxa-glp1-2026"]
    },
    {
      "id": "MX-2026-0413",
      "server": "medRxiv",
      "doi": "10.1101/2026.04.13.000413",
      "title": "Akkermansia muciniphila supplementation in metabolic syndrome: 24-week randomized trial",
      "authors": ["Y. Han", "K. Lee"],
      "affiliations": ["Seoul Metabolic Network"],
      "abstract": "RCT n=160 metabolic syndrome adults. A. muciniphila pasteurized cells reduced HOMA-IR 16% vs placebo. No significant weight change.",
      "posted_date": "2026-04-13",
      "version": 2,
      "subject": "Microbiology",
      "data_links": ["https://osf.io/akk-mets-2026"],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/akk-mets-2026"]
    },
    {
      "id": "BX-2026-0414",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.14.000414",
      "title": "GFRAL-targeting antibody blunts cancer cachexia without affecting tumor growth",
      "authors": ["J. Mueller", "P. Bauer"],
      "affiliations": ["Heidelberg Adiposity Center"],
      "abstract": "Anti-GFRAL Ab in C26 colon cancer cachexia model preserved 78% of lean mass vs controls. Tumor volume unchanged.",
      "posted_date": "2026-04-14",
      "version": 1,
      "subject": "Oncology",
      "data_links": ["https://github.com/heidelberg-adipose/anti-gfral-2026"],
      "code_links": ["https://github.com/heidelberg-adipose/anti-gfral-2026"],
      "protocol_links": ["https://protocols.io/view/anti-gfral-c26-2026"]
    },
    {
      "id": "CX-2026-0416",
      "server": "ChemRxiv",
      "doi": "10.26434/chemrxiv-2026-0416",
      "title": "Long-acting amylin analog cagrilintide: structural basis for sub-cutaneous depot release",
      "authors": ["M. Lindqvist", "F. Lund"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "Crystallography revealed an amyloid-like helical fibril governing slow release. Fibril destabilizing mutations halved half-life.",
      "posted_date": "2026-04-16",
      "version": 1,
      "subject": "Structural Biology",
      "data_links": ["https://github.com/karolinska-obesity/cagri-struct-2026", "https://zenodo.org/record/9000416"],
      "code_links": ["https://github.com/karolinska-obesity/cagri-struct-2026"],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0417",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.17.000417",
      "title": "Single-cell atlas of human inguinal subcutaneous adipose stem cells reveals depot-specific differentiation bias",
      "authors": ["F. Ouellet", "C. Lemieux"],
      "affiliations": ["Montreal Brown Adipose Lab"],
      "abstract": "scRNA-seq of 480,000 ASCs from inguinal SAT. Two depot-restricted progenitor states differ in beige differentiation capacity ex vivo.",
      "posted_date": "2026-04-17",
      "version": 1,
      "subject": "Cell Biology",
      "data_links": ["https://github.com/montreal-bat/asc-atlas-2026", "https://zenodo.org/record/9000417"],
      "code_links": ["https://github.com/montreal-bat/asc-atlas-2026"],
      "protocol_links": ["https://protocols.io/view/asc-atlas-2026"]
    },
    {
      "id": "MX-2026-0418",
      "server": "medRxiv",
      "doi": "10.1101/2026.04.18.000418",
      "title": "Pancreatitis risk with high-dose GLP-1 RA: nested case-control in Korean health insurance data",
      "authors": ["Y. Han", "S. Park"],
      "affiliations": ["Seoul Metabolic Network"],
      "abstract": "Nested case-control 1:4 matching. High-dose semaglutide >=2.0 mg/week OR 1.31 (95% CI 1.05-1.64) for acute pancreatitis vs lower dose.",
      "posted_date": "2026-04-18",
      "version": 1,
      "subject": "Pharmacoepidemiology",
      "data_links": [],
      "code_links": [],
      "protocol_links": []
    },
    {
      "id": "RS-2026-0419",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0419",
      "title": "Adult monogenic obesity prevalence in West African ancestry: targeted resequencing of 8,200 individuals",
      "authors": ["S. Okafor", "A. Eze"],
      "affiliations": ["Lagos Endocrine Research Unit"],
      "abstract": "Targeted resequencing of MC4R, LEPR, POMC, PCSK1 in 8,200 adults. Pathogenic variants in 1.4%, higher than European estimates (0.8%).",
      "posted_date": "2026-04-19",
      "version": 1,
      "subject": "Genetics",
      "data_links": ["https://osf.io/wa-monogenic-2026"],
      "code_links": ["https://github.com/lagos-endo/wa-monogenic-2026"],
      "protocol_links": []
    },
    {
      "id": "BX-2026-0401",
      "server": "bioRxiv",
      "doi": "10.1101/2026.04.01.000401",
      "title": "Glucagon receptor co-agonism preserves lean mass during caloric restriction in DIO mice",
      "authors": ["J. Mueller", "K. Wagner"],
      "affiliations": ["Heidelberg Adiposity Center"],
      "abstract": "Glucagon-only co-agonism in calorie-restricted DIO mice preserved lean mass (-3% vs -11% control) while accelerating fat loss.",
      "posted_date": "2026-04-01",
      "version": 1,
      "subject": "Pharmacology",
      "data_links": ["https://github.com/heidelberg-adipose/gcg-coag-2026"],
      "code_links": ["https://github.com/heidelberg-adipose/gcg-coag-2026"],
      "protocol_links": ["https://protocols.io/view/gcg-coag-cr-2026"]
    },
    {
      "id": "MX-2026-0403",
      "server": "medRxiv",
      "doi": "10.1101/2026.04.03.000403",
      "title": "Resistance training adherence predicts long-term weight loss maintenance: 5-year follow-up",
      "authors": ["S. Okafor", "C. Adesina"],
      "affiliations": ["Lagos Endocrine Research Unit"],
      "abstract": "Long-term follow-up of 540 weight loss maintainers. RT adherence >=2 sessions/week at year 1 predicted weight maintenance OR 3.2 at year 5.",
      "posted_date": "2026-04-03",
      "version": 1,
      "subject": "Sports Medicine",
      "data_links": ["https://osf.io/rt-maintain-2026"],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/rt-maintain-2026"]
    },
    {
      "id": "BX-2026-0319",
      "server": "bioRxiv",
      "doi": "10.1101/2026.03.19.000319",
      "title": "Tanycyte-mediated leptin transport limits central leptin action in DIO",
      "authors": ["M. Lindqvist", "T. Ekman"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "Conditional deletion of leptin receptor on tanycytes paradoxically improved central leptin signaling in DIO mice by extending leptin half-life in CSF.",
      "posted_date": "2026-03-19",
      "version": 2,
      "subject": "Neuroscience",
      "data_links": ["https://github.com/karolinska-obesity/tanycyte-2026"],
      "code_links": ["https://github.com/karolinska-obesity/tanycyte-2026"],
      "protocol_links": ["https://protocols.io/view/tanycyte-cko-2026"]
    },
    {
      "id": "MX-2026-0320",
      "server": "medRxiv",
      "doi": "10.1101/2026.03.20.000320",
      "title": "MRI-derived visceral adipose volume as a stronger predictor of MASLD than BMI",
      "authors": ["L. Costa", "P. Santos"],
      "affiliations": ["Sao Paulo Adipose Biology Lab"],
      "abstract": "Cohort n=1,400 with abdominal MRI. VAT volume AUC 0.84 for MASLD vs BMI AUC 0.71.",
      "posted_date": "2026-03-20",
      "version": 1,
      "subject": "Radiology",
      "data_links": [],
      "code_links": ["https://github.com/sp-adipose/vat-masld-2026"],
      "protocol_links": ["https://protocols.io/view/vat-mri-2026"]
    },
    {
      "id": "CX-2026-0321",
      "server": "ChemRxiv",
      "doi": "10.26434/chemrxiv-2026-0321",
      "title": "First selective FFAR3 agonist for enteroendocrine GLP-1 secretion: structure and PK",
      "authors": ["H. Tanaka", "K. Ito"],
      "affiliations": ["Kyoto Metabolic Institute"],
      "abstract": "Novel scaffold HT-89 binds FFAR3 with 200-fold selectivity over FFAR2. Oral administration boosted post-meal GLP-1 2-fold in mice.",
      "posted_date": "2026-03-21",
      "version": 1,
      "subject": "Medicinal Chemistry",
      "data_links": ["https://github.com/kyoto-metab/ffar3-2026"],
      "code_links": ["https://github.com/kyoto-metab/ffar3-2026"],
      "protocol_links": []
    },
    {
      "id": "RS-2026-0322",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0322",
      "title": "Obesity-related cardiomyopathy reversal after bariatric surgery: cardiac MRI cohort",
      "authors": ["A. Petrov", "I. Sokolov"],
      "affiliations": ["Moscow Bariatric Clinic"],
      "abstract": "Pre and 24-month post-bariatric cardiac MRI in 120 patients. LV mass index normalized in 78%. Diastolic function improved in 64%.",
      "posted_date": "2026-03-22",
      "version": 2,
      "subject": "Cardiology",
      "data_links": [],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/bariatric-cardiac-2026"]
    },
    {
      "id": "BX-2026-0323",
      "server": "bioRxiv",
      "doi": "10.1101/2026.03.23.000323",
      "title": "Cross-post identical preprint on Research Square and bioRxiv detection benchmark",
      "authors": ["F. Ouellet", "P. Beaulieu"],
      "affiliations": ["Montreal Brown Adipose Lab"],
      "abstract": "Beige adipocyte recruitment via CL316,243 fails in aged mice due to senescent ASC accumulation. Replication of RS-2026-0514 with extended cohort.",
      "posted_date": "2026-03-23",
      "version": 1,
      "subject": "Aging",
      "data_links": ["https://github.com/montreal-bat/beige-senescence-2026"],
      "code_links": ["https://github.com/montreal-bat/beige-senescence-2026"],
      "protocol_links": []
    },
    {
      "id": "MX-2026-0324",
      "server": "medRxiv",
      "doi": "10.1101/2026.03.24.000324",
      "title": "Childhood adiposity rebound timing and adult cardiometabolic risk: Lisbon birth cohort follow-up",
      "authors": ["K. Almeida", "J. Sousa"],
      "affiliations": ["Lisbon Pediatric Obesity Cohort"],
      "abstract": "Earlier adiposity rebound (<5 years) associated with adult MetS risk OR 2.7 at age 25.",
      "posted_date": "2026-03-24",
      "version": 1,
      "subject": "Epidemiology",
      "data_links": ["https://osf.io/lisbon-rebound-2026"],
      "code_links": ["https://github.com/lisbon-peds/rebound-2026"],
      "protocol_links": []
    },
    {
      "id": "RS-2026-0325",
      "server": "Research Square",
      "doi": "10.21203/rs.3.rs.0325",
      "title": "Plasma proteomics signature of GLP-1 RA response: discovery and validation cohorts",
      "authors": ["R. Devarajan", "K. Vasudevan"],
      "affiliations": ["Chennai Diabetes Research Foundation"],
      "abstract": "SomaScan 7K proteomics on n=420 GLP-1 RA initiators. 38-protein signature predicted >10% weight loss AUC 0.81; validated in n=210.",
      "posted_date": "2026-03-25",
      "version": 1,
      "subject": "Proteomics",
      "data_links": ["https://github.com/chennai-drf/glp1-proteomics-2026", "https://zenodo.org/record/9000325"],
      "code_links": ["https://github.com/chennai-drf/glp1-proteomics-2026"],
      "protocol_links": ["https://protocols.io/view/glp1-proteomics-2026"]
    },
    {
      "id": "BX-2026-0326",
      "server": "bioRxiv",
      "doi": "10.1101/2026.03.26.000326",
      "title": "AAV-mediated hypothalamic POMC overexpression rescues hyperphagia in LEPR-deficient mice",
      "authors": ["M. Lindqvist", "S. Johansson"],
      "affiliations": ["Karolinska Obesity Center"],
      "abstract": "AAV-PHP.eB delivery of POMC to arcuate nucleus reduced food intake 32% in db/db mice over 8 weeks.",
      "posted_date": "2026-03-26",
      "version": 1,
      "subject": "Gene Therapy",
      "data_links": ["https://github.com/karolinska-obesity/aav-pomc-2026"],
      "code_links": ["https://github.com/karolinska-obesity/aav-pomc-2026"],
      "protocol_links": ["https://protocols.io/view/aav-pomc-2026"]
    },
    {
      "id": "MX-2026-0327",
      "server": "medRxiv",
      "doi": "10.1101/2026.03.27.000327",
      "title": "Frailty trajectories in older adults with sarcopenic obesity on GLP-1 RA",
      "authors": ["Y. Han", "M. Lee"],
      "affiliations": ["Seoul Metabolic Network"],
      "abstract": "Prospective cohort n=420 adults >=70 on semaglutide. Frailty index increased in 28% sarcopenic obesity subgroup vs 11% non-sarcopenic.",
      "posted_date": "2026-03-27",
      "version": 1,
      "subject": "Geriatrics",
      "data_links": [],
      "code_links": [],
      "protocol_links": ["https://protocols.io/view/frail-sarc-glp1-2026"]
    },
    {
      "id": "BX-2026-0328",
      "server": "bioRxiv",
      "doi": "10.1101/2026.03.28.000328",
      "title": "Gut-brain vagal afferent signaling required for GLP-1 RA anti-obesity effect",
      "authors": ["H. Tanaka", "Y. Sato"],
      "affiliations": ["Kyoto Metabolic Institute"],
      "abstract": "Subdiaphragmatic vagotomy abolished 60% of semaglutide-induced food intake reduction in DIO mice. CNS injection bypassed this requirement.",
      "posted_date": "2026-03-28",
      "version": 1,
      "subject": "Neuroscience",
      "data_links": ["https://github.com/kyoto-metab/vagus-glp1-2026"],
      "code_links": ["https://github.com/kyoto-metab/vagus-glp1-2026"],
      "protocol_links": []
    }
  ]
}